{"type":"trials","record":{"id":21652,"source_id":"clinicaltrials-gov","external_id":"NCT03754842","title":"Effect of Nicotinamide Riboside and Pterostilbene Supplementation on Muscle Regeneration in Elderly Humans","brief_summary":"Successful skeletal muscle regeneration depends on a functional pool of muscle stem cells, termed satellite cells (SC). SC are in a quiescent state throughout adulthood, but undergo multiple cycles of proliferation and self-renewal in response to muscle damage. During aging, there is a loss of SC quiescence, and SC more readily enter an ageing-state impairing their function. Animal studies have revealed a common denominator for increasing SC function and activity, namely Sirtuin activation. Natural stimulators of Sirtuins includes Nicotinamide Riboside (NR) (a Nicotinamide adenine dinucleotide (NAD+) precursor) and the polyphenol Pterostilbene (PT). In this study, we aim to investigate if NR+PT supplementation will promote skeletal muscle regeneration after muscle damage in elderly humans by enhanced recruitment of SC.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University of Aarhus","enrollment":32,"countries":["Denmark"],"start_date":"2019-02-12","completion_date":"2020-09-01","last_update_date":"2020-11-05","source_url":"https://clinicaltrials.gov/study/NCT03754842","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:08.26846+00:00","last_seen_at":"2026-09-25T06:05:48.982+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"55 Years to 80 Years","comparator":"Placebo","organization":"University of Aarhus","interventions":["Placebo (twice daily)","Nicotinamide Riboside/Pterostilbene (500 mg/100 mg twice daily)"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Presence of Satellite Cells — Change from baseline up to 45 days","Activation of Satellite cells — Change from baseline up to 45 days","Presence of macrophages — Change from baseline up to 45 days","Presence of Fibro/Adipogenic Progenitors — Change from baseline up to 45 days","Presence of damaged muscle fibers — Change from baseline up to 45 days","Presence of muscle regenerative fibers — Change from baseline up to 45 days","Presence of autophagy in relation to muscle damage — Change from baseline up to 45 days","Lipid accumulation in skeletal muscle tissue and liver — Change from baseline to 8 days","Blood glucose response in relation to muscle damage — Change from baseline to 8 days","Body composition (lean body mass and fat body mass) — Change from baseline to 45 days","Muscle strength — Change from baseline up to 45 days"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · QUADRUPLE","source_has_results":false},"controlled_terms":["Muscle Injury","Placebo (twice daily)","Nicotinamide Riboside/Pterostilbene (500 mg/100 mg twice daily)"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: nicotinamide riboside.","quality_checked_at":"2026-09-25T06:05:49.860138+00:00","duplicate_cluster_key":"id:nct03754842","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2019-02-12 to 2020-09-01","comparator":"Placebo","confidence":"structured-source","population":"ALL · 55 Years to 80 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:05:48.989Z","intervention":["Placebo (twice daily)","Nicotinamide Riboside/Pterostilbene (500 mg/100 mg twice daily)"],"participants":32,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · QUADRUPLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Presence of Satellite Cells — Change from baseline up to 45 days","Activation of Satellite cells — Change from baseline up to 45 days","Presence of macrophages — Change from baseline up to 45 days","Presence of Fibro/Adipogenic Progenitors — Change from baseline up to 45 days","Presence of damaged muscle fibers — Change from baseline up to 45 days","Presence of muscle regenerative fibers — Change from baseline up to 45 days","Presence of autophagy in relation to muscle damage — Change from baseline up to 45 days","Lipid accumulation in skeletal muscle tissue and liver — Change from baseline to 8 days","Blood glucose response in relation to muscle damage — Change from baseline to 8 days","Body composition (lean body mass and fat body mass) — Change from baseline to 45 days","Muscle strength — Change from baseline up to 45 days"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"nad-metabolism","is_published":true,"match_reasons":["Title contains controlled term: nicotinamide riboside.","Abstract contains controlled term: nad+, nicotinamide riboside.","Source terminology contains: nicotinamide riboside.","Title supplies longevity context: elderly.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"NAD metabolism","slug":"nad-metabolism"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/21652","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}