{"type":"trials","record":{"id":21662,"source_id":"clinicaltrials-gov","external_id":"NCT06633978","title":"Studying the Effects of Digital Interventions on Cognition, Wellbeing, Stress, and Sleep in Older Adults","brief_summary":"The goal of this proposed research is to collect pilot data to test the hypothesis that treatment with a novel form of closed-loop digital meditation (MediTrain) will lead to a greater magnitude of gains in cognitive abilities in patients with mild cognitive impairment (MCI), compared to OA without cognitive impairment, and will lead to improvements in quantitative measures of sleep.","overall_status":"Active Not Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University of California, San Francisco","enrollment":90,"countries":["United States"],"start_date":"2024-09-10","completion_date":"2026-08-01","last_update_date":"2026-08-24","source_url":"https://clinicaltrials.gov/study/NCT06633978","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Active Not Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:08.972024+00:00","last_seen_at":"2026-09-25T06:05:20.497+00:00","metadata":{"sex":"ALL","acronym":"MediDream","age_range":"60 Years to 85 Years","comparator":null,"organization":"University of California, San Francisco","interventions":["MediTrain","wrist worn multi-sensor watches","Sleep monitor"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Mean change on the Continuous Performance Task (CPT) over time — baseline, immediate follow-up, and at a 6 month follow…","Mean change in sleep quality — baseline, immediate follow-up, and at a 6 month follow-up in a subset of participants","Mean change in measures of stress reactivity over time — baseline, immediate follow-up, and at a 6 month follow-up in a…","Mean change in Telomere length (quantified in peripheral blood cells) over time — baseline, immediate follow-up, and at…","Mean change on a distracted attention task over time — baseline, immediate follow-up, and at a 6 month follow-up in a s…","Mean change in Frontal Theta Power over time — baseline, immediate follow-up, and at a 6 month follow-up in a subset of…","Mean change in resting state networks over time — baseline, immediate follow-up, and at a 6 month follow-up in a subset…"],"design_description":"NA · SINGLE GROUP · PREVENTION · NONE","source_has_results":false},"controlled_terms":["MCI","Aging","MediTrain","wrist worn multi-sensor watches","Sleep monitor"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: sleep.","quality_checked_at":"2026-09-25T06:05:21.960425+00:00","duplicate_cluster_key":"id:nct06633978","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2024-09-10 to 2026-08-01","comparator":null,"confidence":"structured-source","population":"ALL · 60 Years to 85 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:05:20.499Z","intervention":["MediTrain","wrist worn multi-sensor watches","Sleep monitor"],"participants":90,"study_design":"NA · SINGLE GROUP · PREVENTION · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Mean change on the Continuous Performance Task (CPT) over time — baseline, immediate follow-up, and at a 6 month follow…","Mean change in sleep quality — baseline, immediate follow-up, and at a 6 month follow-up in a subset of participants","Mean change in measures of stress reactivity over time — baseline, immediate follow-up, and at a 6 month follow-up in a…","Mean change in Telomere length (quantified in peripheral blood cells) over time — baseline, immediate follow-up, and at…","Mean change on a distracted attention task over time — baseline, immediate follow-up, and at a 6 month follow-up in a s…","Mean change in Frontal Theta Power over time — baseline, immediate follow-up, and at a 6 month follow-up in a subset of…","Mean change in resting state networks over time — baseline, immediate follow-up, and at a 6 month follow-up in a subset…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"sleep","is_published":true,"match_reasons":["Title contains controlled term: sleep.","Abstract contains controlled term: sleep.","Source terminology contains: sleep.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Sleep","slug":"sleep"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/21662","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}