{"type":"trials","record":{"id":21684,"source_id":"clinicaltrials-gov","external_id":"NCT07479940","title":"Obesity and Aging: Impacts of Nutritional Counseling and Physical Exercise on Telomeres and Senescence Parameters","brief_summary":"The study will involve 80 elderly women, 40 eutrophic and 40 obese, divided into four groups, each with n=20. 1) Eutrophic Group (EG) undergoing only nutritional counseling (NC), 2) Eutrophic Group with NC and combined training (CT), 3) Obese Group (OG) undergoing only NC, and 4) Obese Group with NC and CT. The study will be divided into two main phases: an initial 9-week phase dedicated to NC, followed by a 20-week CT phase.","overall_status":"Active Not Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University of Sao Paulo","enrollment":60,"countries":["Brazil"],"start_date":"2026-03-01","completion_date":"2026-10-20","last_update_date":"2026-03-20","source_url":"https://clinicaltrials.gov/study/NCT07479940","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Active Not Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:08.972024+00:00","last_seen_at":"2026-09-25T06:15:54.38+00:00","metadata":{"sex":"FEMALE","acronym":null,"age_range":"60 Years to 75 Years","comparator":"Eutrophic Group (ECG); Obesity Group (OCG)","organization":"University of Sao Paulo","interventions":["Combined Training","Nutritional Counseling"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Telomere length in peripheral blood mononuclear cells (PBMCs) measured by quantitative PCR — 9 and 29 weeks","Expression of cellular senescence-related genes in PBMCs measured by quantitative RT-PCR — 9 and 29 weeks","Adequacy of protein intake assessed by dietary intake analysis — 0, 9 and 29 weeks","Percentage of ultra-processed food consumption assessed by NOVA food classification — 0, 9 and 29 weeks","Diet quality assessed by proportion of ultra-processed food consumption according to the NOVA classification — 0, 9 and…","Expression of telomere-related genes measured by RT-qPCR — 9 and 29 weeks","Expression of cellular senescence-associated genes in peripheral blood mononuclear cells measured by RT-qPCR — 9 and 29…","Redox state analysis; — 9 and 29 weeks","Analysis of mitochondrial function — 9 and 29 weeks","Determination of nitrogen balance — 9 and 29 weeks","Cardiorespiratory capacity assessed by incremental cycling test with blood lactate measurement — 9 and 29 weeks","Lower limb muscle strength assessed by isokinetic dynamometry — 9 and 29 weeks","Upper body functional strength assessed by the arm curl test — 9 and 29 weeks","Functional mobility assessed by the Timed Up and Go test — 9 and 29 weeks","Handgrip strength measured using a hand dynamometer — 9 and 29 weeks","Body composition assessed by dual-energy X-ray absorptiometry (DXA) — 9 and 29 weeks","Body mass index calculated from measured weight and height — 9 and 29 weeks","Waist-to-hip ratio calculated from anthropometric measurements — 9 and 29 weeks"],"design_description":"RANDOMIZED · PARALLEL · HEALTH SERVICES RESEARCH · NONE","source_has_results":false},"controlled_terms":["Aging","Obesity","Nutrition","Exercise","Telomere Shortening","Inflammation","Oxidative Stress","Oxidative DNA Damage","Combined Training","Nutritional Counseling"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":85,"publication_state":"published","match_explanation":"Title contains controlled term: exercise.","quality_checked_at":"2026-09-25T06:16:07.48358+00:00","duplicate_cluster_key":"id:nct07479940","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2026-03-01 to 2026-10-20","comparator":"Eutrophic Group (ECG); Obesity Group (OCG)","confidence":"structured-source","population":"FEMALE · 60 Years to 75 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:54.415Z","intervention":["Combined Training","Nutritional Counseling"],"participants":60,"study_design":"RANDOMIZED · PARALLEL · HEALTH SERVICES RESEARCH · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Telomere length in peripheral blood mononuclear cells (PBMCs) measured by quantitative PCR — 9 and 29 weeks","Expression of cellular senescence-related genes in PBMCs measured by quantitative RT-PCR — 9 and 29 weeks","Adequacy of protein intake assessed by dietary intake analysis — 0, 9 and 29 weeks","Percentage of ultra-processed food consumption assessed by NOVA food classification — 0, 9 and 29 weeks","Diet quality assessed by proportion of ultra-processed food consumption according to the NOVA classification — 0, 9 and…","Expression of telomere-related genes measured by RT-qPCR — 9 and 29 weeks","Expression of cellular senescence-associated genes in peripheral blood mononuclear cells measured by RT-qPCR — 9 and 29…","Redox state analysis; — 9 and 29 weeks","Analysis of mitochondrial function — 9 and 29 weeks","Determination of nitrogen balance — 9 and 29 weeks","Cardiorespiratory capacity assessed by incremental cycling test with blood lactate measurement — 9 and 29 weeks","Lower limb muscle strength assessed by isokinetic dynamometry — 9 and 29 weeks","Upper body functional strength assessed by the arm curl test — 9 and 29 weeks","Functional mobility assessed by the Timed Up and Go test — 9 and 29 weeks","Handgrip strength measured using a hand dynamometer — 9 and 29 weeks","Body composition assessed by dual-energy X-ray absorptiometry (DXA) — 9 and 29 weeks","Body mass index calculated from measured weight and height — 9 and 29 weeks","Waist-to-hip ratio calculated from anthropometric measurements — 9 and 29 weeks"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"exercise","is_published":true,"match_reasons":["Title contains controlled term: exercise.","Source terminology contains: exercise.","Title supplies longevity context: aging, senescence.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Exercise","slug":"exercise"}},{"topic_slug":"telomeres-telomerase","is_published":true,"match_reasons":["Title contains controlled term: telomere.","Source terminology contains: telomere.","Title supplies longevity context: aging, senescence.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Telomeres and telomerase","slug":"telomeres-telomerase"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/21684","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}