{"type":"trials","record":{"id":21726,"source_id":"clinicaltrials-gov","external_id":"NCT06942351","title":"Effect of Walnuts on Cognitive Function and Gut Microbiome in Older Adults","brief_summary":"The purpose of this study is to examine the impact of daily consumption of walnuts for 12 weeks on cognitive function, markers of inflammation and oxidative stress, and the gut microbiome in healthy adults age 55 years and older.","overall_status":"Active Not Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Oregon State University","enrollment":90,"countries":["United States"],"start_date":"2025-06-09","completion_date":"2029-05-01","last_update_date":"2026-08-07","source_url":"https://clinicaltrials.gov/study/NCT06942351","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Active Not Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:09.678176+00:00","last_seen_at":"2026-09-25T06:15:54.38+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"55 Years","comparator":"Walnuts; Crackers","organization":"Oregon State University","interventions":["Walnuts","Crackers"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Cognitive function - memory, age adjusted — 0 and 12 weeks","Cognitive function - memory, proximity — 0 and 12 weeks","Cognitive function - cognitive flexibility, age adjusted — 0 and 12 weeks","Cognitive function - cognitive flexibility, proximity — 0 and 12 weeks","Cognitive function - speed of processing — 0 and 12 weeks","Gut microbiome composition — 0 and 12 weeks","Lipid oxidation levels — 0 and 12 weeks","Gut permeability and health: Inflammatory biomarkers — 0 and 12 weeks","Biomarkers of inflammation — 0 and 12 weeks","Urolithin concentrations — 0 and 12 weeks","Blood pressure — 0 and 12 weeks","Weight — 0 and 12 weeks"],"design_description":"RANDOMIZED · PARALLEL · BASIC SCIENCE · SINGLE","source_has_results":false},"controlled_terms":["Aging","Inflammation Biomarkers","Walnuts","Crackers"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: microbiome.","quality_checked_at":"2026-09-25T06:16:07.48358+00:00","duplicate_cluster_key":"id:nct06942351","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-06-09 to 2029-05-01","comparator":"Walnuts; Crackers","confidence":"structured-source","population":"ALL · 55 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:54.396Z","intervention":["Walnuts","Crackers"],"participants":90,"study_design":"RANDOMIZED · PARALLEL · BASIC SCIENCE · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Cognitive function - memory, age adjusted — 0 and 12 weeks","Cognitive function - memory, proximity — 0 and 12 weeks","Cognitive function - cognitive flexibility, age adjusted — 0 and 12 weeks","Cognitive function - cognitive flexibility, proximity — 0 and 12 weeks","Cognitive function - speed of processing — 0 and 12 weeks","Gut microbiome composition — 0 and 12 weeks","Lipid oxidation levels — 0 and 12 weeks","Gut permeability and health: Inflammatory biomarkers — 0 and 12 weeks","Biomarkers of inflammation — 0 and 12 weeks","Urolithin concentrations — 0 and 12 weeks","Blood pressure — 0 and 12 weeks","Weight — 0 and 12 weeks"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"microbiome-dysbiosis","is_published":true,"match_reasons":["Title contains controlled term: microbiome.","Abstract contains controlled term: microbiome.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Microbiome and dysbiosis","slug":"microbiome-dysbiosis"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/21726","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}