{"type":"trials","record":{"id":21773,"source_id":"clinicaltrials-gov","external_id":"NCT06592859","title":"Intervention of Nicotinamide Mononucleotide in Middle-aged and Elderly People","brief_summary":"This study is a single-center, randomized, double-blind, placebo-controlled clinical trial investigating a pharmacological intervention for aging. Its primary objective is to evaluate the efficacy of NMN while ensuring the safety of oral administration, with the aim of identifying effective strategies to delay aging and improve the quality of life in the elderly population. The main outcomes of this study are to characterize the patterns of NMN efficacy across different populations and to identify sensitive biomarkers that reflect responsiveness to the intervention.","overall_status":"Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"People's Hospital of Quzhou","enrollment":240,"countries":["China"],"start_date":"2023-08-23","completion_date":"2026-12-31","last_update_date":"2026-05-08","source_url":"https://clinicaltrials.gov/study/NCT06592859","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:10.338673+00:00","last_seen_at":"2026-09-25T06:15:13.984+00:00","metadata":{"sex":"ALL","acronym":"NMNAGING","age_range":"39 Years to 70 Years","comparator":"Placebo (middle-aged male); Placebo (middle-aged female); Placebo (old male); Placebo (old female)","organization":"People's Hospital of Quzhou","interventions":["NMN","placebo"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Comprehensive evaluation of NMN in reducing biological age — Baseline, 6 months and 12 months","Composite through clinical physical examination data, behavioral indicators and multilevel omics data, to discover new…"],"design_description":"RANDOMIZED · PARALLEL · BASIC SCIENCE · DOUBLE","source_has_results":false},"controlled_terms":["Aging","NMN","placebo"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: nicotinamide mononucleotide.","quality_checked_at":"2026-09-25T06:15:15.562724+00:00","duplicate_cluster_key":"id:nct06592859","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2023-08-23 to 2026-12-31","comparator":"Placebo (middle-aged male); Placebo (middle-aged female); Placebo (old male); Placebo (old female)","confidence":"structured-source","population":"ALL · 39 Years to 70 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:13.995Z","intervention":["NMN","placebo"],"participants":240,"study_design":"RANDOMIZED · PARALLEL · BASIC SCIENCE · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Comprehensive evaluation of NMN in reducing biological age — Baseline, 6 months and 12 months","Composite through clinical physical examination data, behavioral indicators and multilevel omics data, to discover new…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"nad-metabolism","is_published":true,"match_reasons":["Title contains controlled term: nicotinamide mononucleotide.","Abstract contains controlled term: nmn.","Source terminology contains: nmn.","Title supplies longevity context: elderly.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"NAD metabolism","slug":"nad-metabolism"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/21773","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}