{"type":"trials","record":{"id":21796,"source_id":"clinicaltrials-gov","external_id":"NCT03818802","title":"Effects of Vitamin B3 Derivative Nicotinamide Riboside (NR) in Bone, Skeletal Muscle and Metabolic Functions in Aging","brief_summary":"Researchers are trying to determine if the vitamin B3 derivative Nicotinamide Riboside (NR) has any effects in bone, skeletal muscle, and metabolic functions and structure in aging.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Mayo Clinic","enrollment":53,"countries":["United States"],"start_date":"2019-09-16","completion_date":"2024-11-08","last_update_date":"2025-02-26","source_url":"https://clinicaltrials.gov/study/NCT03818802","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:10.338673+00:00","last_seen_at":"2026-09-25T07:05:20.248+00:00","metadata":{"sex":"FEMALE","acronym":null,"age_range":"65 Years to 80 Years","comparator":"Nicotinamide Riboside; Placebo","organization":"Mayo Clinic","interventions":["Nicotinamide Riboside","Placebo"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Maximal oxygen uptake (VO2 max) test — 6 months","Skeletal muscle function — 6 months","Short Physical Performance Battery (SPPB) — 6 months","Respiration rate on muscle biopsy samples — 6 months","PCR on muscle biopsy samples — 6 months","Immunoblot on muscle biopsy samples — 6 months","Bone metabolism — 6 months","Glucose profile — 6 months","Insulin — 6 months","Lipid profile — 6 months","Hemoglobin A1C — 6 months","Oral glucose tolerance test — 6 months"],"design_description":"RANDOMIZED · PARALLEL · PREVENTION · DOUBLE","source_has_results":false},"controlled_terms":["Healthy Elderly Volunteers","Nicotinamide Riboside","Placebo"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: nicotinamide riboside.","quality_checked_at":"2026-09-25T07:05:30.295959+00:00","duplicate_cluster_key":"id:nct03818802","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2019-09-16 to 2024-11-08","comparator":"Nicotinamide Riboside; Placebo","confidence":"structured-source","population":"FEMALE · 65 Years to 80 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T07:05:20.307Z","intervention":["Nicotinamide Riboside","Placebo"],"participants":53,"study_design":"RANDOMIZED · PARALLEL · PREVENTION · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Maximal oxygen uptake (VO2 max) test — 6 months","Skeletal muscle function — 6 months","Short Physical Performance Battery (SPPB) — 6 months","Respiration rate on muscle biopsy samples — 6 months","PCR on muscle biopsy samples — 6 months","Immunoblot on muscle biopsy samples — 6 months","Bone metabolism — 6 months","Glucose profile — 6 months","Insulin — 6 months","Lipid profile — 6 months","Hemoglobin A1C — 6 months","Oral glucose tolerance test — 6 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"nad-metabolism","is_published":true,"match_reasons":["Title contains controlled term: nicotinamide riboside.","Abstract contains controlled term: nicotinamide riboside.","Source terminology contains: nicotinamide riboside.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"NAD metabolism","slug":"nad-metabolism"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/21796","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}