{"type":"trials","record":{"id":21822,"source_id":"clinicaltrials-gov","external_id":"NCT06635369","title":"Taurine in Periodontitis and Aging","brief_summary":"Aging leads to a decline in physiological functions and increases the risk of chronic diseases. Periodontitis is a chronic inflammatory disease that causes progressive destruction of the tissues supporting the teeth. Taurine, an amino acid with anti-inflammatory and antioxidant effects, might impact both periodontitis and aging. This study investigated taurine, SIRT1, and TNF-α levels in saliva and blood of 66 healthy people in different age groups, with or without periodontal disease. The findings showed that young people with healthy periodontal status had higher levels of taurine and SIRT1 compared to others. TNF-α, a marker of inflammation, was linked to the severity of periodontitis and may help identifying it in younger individuals. Overall, higher TNF-α levels are associated with periodontal inflammation, while taurine levels decrease with age-related inflammation.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Istanbul Medipol University Hospital","enrollment":66,"countries":["Turkey (Türkiye)"],"start_date":"2023-12-21","completion_date":"2024-06-01","last_update_date":"2024-10-10","source_url":"https://clinicaltrials.gov/study/NCT06635369","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:10.897288+00:00","last_seen_at":"2026-09-25T06:25:08.953+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"26 Years","comparator":null,"organization":"Istanbul Medipol University Hospital","interventions":["Periodontal Indices"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Taurine — 12 Weeks","SIRT1 — 12 Weeks","TNF-α — 12 Weeks"],"design_description":"NON RANDOMIZED · PARALLEL · DIAGNOSTIC · NONE","source_has_results":false},"controlled_terms":["Peridontal Disease","Aging","Periodontal Indices"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: periodontitis.","quality_checked_at":"2026-09-25T06:25:14.10514+00:00","duplicate_cluster_key":"id:nct06635369","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2023-12-21 to 2024-06-01","comparator":null,"confidence":"structured-source","population":"ALL · 26 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:25:09.007Z","intervention":["Periodontal Indices"],"participants":66,"study_design":"NON RANDOMIZED · PARALLEL · DIAGNOSTIC · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Taurine — 12 Weeks","SIRT1 — 12 Weeks","TNF-α — 12 Weeks"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"oral-health-aging","is_published":true,"match_reasons":["Title contains controlled term: periodontitis.","Abstract contains controlled term: periodontitis.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Oral health and ageing","slug":"oral-health-aging"}},{"topic_slug":"taurine","is_published":true,"match_reasons":["Title contains controlled term: taurine.","Abstract contains controlled term: taurine.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Taurine","slug":"taurine"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/21822","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}