{"type":"trials","record":{"id":21833,"source_id":"clinicaltrials-gov","external_id":"NCT01567176","title":"Circulating SIRT6 Expression, Effect on Aging Quality","brief_summary":"This study follows the results of the COMPALICLAMP study (NCT00951392) where the investigators showed a differential expression of sirtuins protein isoforms, Sirt6, in muscle depending on the quality of aging. The investigators seek to confirm this difference in expression level of circulating leukocytes on a larger sample.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Hospices Civils de Lyon","enrollment":60,"countries":["France"],"start_date":"2012-03-01","completion_date":"2012-09-01","last_update_date":"2019-05-28","source_url":"https://clinicaltrials.gov/study/NCT01567176","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:10.897288+00:00","last_seen_at":"2026-09-25T06:05:48.982+00:00","metadata":{"sex":"ALL","acronym":"Sirt6","age_range":"60 Years","comparator":null,"organization":"Hospices Civils de Lyon","interventions":["Blood sample"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Sirt6 expression in circulating leukocytes based on the aging quality — participants will be followed for the duration…","hand and forearm muscular strength measurement — participants will be followed for the duration of the visit, an expect…","Physical examination and anthropometric measurement — participants will be followed for the duration of the visit, an e…","Cognitive assessment — participants will be followed for the duration of the visit, an expected average of 1 day","Physical Activity questionnaire — participants will be followed for the duration of the visit, an expected average of 1…"],"design_description":"NA · SINGLE GROUP · BASIC SCIENCE · NONE","source_has_results":false},"controlled_terms":["Aging","Blood sample"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: sirt6.","quality_checked_at":"2026-09-25T06:05:49.860138+00:00","duplicate_cluster_key":"id:nct01567176","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2012-03-01 to 2012-09-01","comparator":null,"confidence":"structured-source","population":"ALL · 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:05:48.990Z","intervention":["Blood sample"],"participants":60,"study_design":"NA · SINGLE GROUP · BASIC SCIENCE · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Sirt6 expression in circulating leukocytes based on the aging quality — participants will be followed for the duration…","hand and forearm muscular strength measurement — participants will be followed for the duration of the visit, an expect…","Physical examination and anthropometric measurement — participants will be followed for the duration of the visit, an e…","Cognitive assessment — participants will be followed for the duration of the visit, an expected average of 1 day","Physical Activity questionnaire — participants will be followed for the duration of the visit, an expected average of 1…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"sirtuins","is_published":true,"match_reasons":["Title contains controlled term: sirt6.","Abstract contains controlled term: sirtuin, sirt6.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Sirtuins","slug":"sirtuins"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/21833","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}