{"type":"trials","record":{"id":21881,"source_id":"clinicaltrials-gov","external_id":"NCT05842447","title":"Effect of Pomanox® on Skin Ageing (POMASKIN)","brief_summary":"The state of skin health impacts not only on the general health of individuals, but also on mental health. Ultraviolet radiation (UV) is one of the main external factors that causes skin ageing, producing photo-aging, characterized by multiple alterations in the skin such as the appearance of wrinkles, dryness, erythema, alterations in the pigmentation, inflammation and increased fragility. Several studies show that polyphenols extracts, including pomegranate extracts, have beneficial effects on various skin characteristics induced by photoaging by modulating internal factors that lead to changes associated with photoaging. Among these internal factors are oxidative stress, glycation stress caused by an accumulation of advances glycation end-products (AGEs), inflammation, and the composition of the intestinal and skin microbiota. Pomanox® is a polyphenolic extract derived from pomegranate for which antioxidant activity and positive effects on the metabolism of collagen and hyaluronic acid have been shown in previous in vitro studies.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Fundació Eurecat","enrollment":66,"countries":["Spain"],"start_date":"2023-10-16","completion_date":"2024-10-28","last_update_date":"2024-10-30","source_url":"https://clinicaltrials.gov/study/NCT05842447","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:11.779627+00:00","last_seen_at":"2026-09-25T06:20:14.553+00:00","metadata":{"sex":"FEMALE","acronym":"POMASKIN","age_range":"30 Years to 65 Years","comparator":"Control group","organization":"Fundació Eurecat","interventions":["367 mg Pomanox group","700 mg Pomanox group","Control group"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in skin melanin index. — At day 1 (visit V1), day 29 (visit 2) and day 85 (visit 3).","Change in skin wrinkles. — At day 1 (visit V1), day 29 (visit 2) and day 85 (visit 3).","Change in skin hydratation. — At day 1 (visit V1), day 29 (visit 2) and day 85 (visit 3).","Change in skin elasticity. — At day 1 (visit V1), day 29 (visit 2) and day 85 (visit 3).","Change in skin erythema index. — At day 1 (visit V1), day 29 (visit 2) and day 85 (visit 3).","Change in skin pores. — At day 1 (visit V1), day 29 (visit 2) and day 85 (visit 3).","Change in skin acne. — At day 1 (visit V1), day 29 (visit 2) and day 85 (visit 3).","Change in skin keratin. — At day 1 (visit V1), day 29 (visit 2) and day 85 (visit 3).","Change in Human Procollagen I N-Terminal Propeptide blood levels. — At day 1 (visit V1) and day 85 (visit 3).","Change in Human Procollagen I C-Terminal Propeptide blood levels. — At day 1 (visit V1) and day 85 (visit 3).","Change in Metalloproteinase-1 blood levels. — At day 1 (visit V1) and day 85 (visit 3).","Change in hyaluronic acid blood levels. — At day 1 (visit V1) and day 85 (visit 3).","Change in superoxide dismutase activity blood levels. — At day 1 (visit V1) and day 85 (visit 3).","Change in reduced gluthathione blood levels. — At day 1 (visit V1) and day 85 (visit 3).","Change in pentosidine blood levels. — At day 1 (visit V1) and day 85 (visit 3).","Change in carboxymethyl-lysine blood levels. — At day 1 (visit V1) and day 85 (visit 3).","Change in interleukin-1 alpha blood levels. — At day 1 (visit V1) and day 85 (visit 3).","Change in interleukin-6 blood levels. — At day 1 (visit V1) and day 85 (visit 3).","Change in stool microbiota composition. — At day 1 (visit V1) and day 85 (visit 3).","Change in skin microbiota composition. — At day 1 (visit V1) and day 85 (visit 3)."],"design_description":"RANDOMIZED · PARALLEL · PREVENTION · QUADRUPLE","source_has_results":false},"controlled_terms":["Skin Ageing","367 mg Pomanox group","700 mg Pomanox group","Control group"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: skin ageing.","quality_checked_at":"2026-09-25T06:20:17.523592+00:00","duplicate_cluster_key":"id:nct05842447","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2023-10-16 to 2024-10-28","comparator":"Control group","confidence":"structured-source","population":"FEMALE · 30 Years to 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:14.579Z","intervention":["367 mg Pomanox group","700 mg Pomanox group","Control group"],"participants":66,"study_design":"RANDOMIZED · PARALLEL · PREVENTION · QUADRUPLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in skin melanin index. — At day 1 (visit V1), day 29 (visit 2) and day 85 (visit 3).","Change in skin wrinkles. — At day 1 (visit V1), day 29 (visit 2) and day 85 (visit 3).","Change in skin hydratation. — At day 1 (visit V1), day 29 (visit 2) and day 85 (visit 3).","Change in skin elasticity. — At day 1 (visit V1), day 29 (visit 2) and day 85 (visit 3).","Change in skin erythema index. — At day 1 (visit V1), day 29 (visit 2) and day 85 (visit 3).","Change in skin pores. — At day 1 (visit V1), day 29 (visit 2) and day 85 (visit 3).","Change in skin acne. — At day 1 (visit V1), day 29 (visit 2) and day 85 (visit 3).","Change in skin keratin. — At day 1 (visit V1), day 29 (visit 2) and day 85 (visit 3).","Change in Human Procollagen I N-Terminal Propeptide blood levels. — At day 1 (visit V1) and day 85 (visit 3).","Change in Human Procollagen I C-Terminal Propeptide blood levels. — At day 1 (visit V1) and day 85 (visit 3).","Change in Metalloproteinase-1 blood levels. — At day 1 (visit V1) and day 85 (visit 3).","Change in hyaluronic acid blood levels. — At day 1 (visit V1) and day 85 (visit 3).","Change in superoxide dismutase activity blood levels. — At day 1 (visit V1) and day 85 (visit 3).","Change in reduced gluthathione blood levels. — At day 1 (visit V1) and day 85 (visit 3).","Change in pentosidine blood levels. — At day 1 (visit V1) and day 85 (visit 3).","Change in carboxymethyl-lysine blood levels. — At day 1 (visit V1) and day 85 (visit 3).","Change in interleukin-1 alpha blood levels. — At day 1 (visit V1) and day 85 (visit 3).","Change in interleukin-6 blood levels. — At day 1 (visit V1) and day 85 (visit 3).","Change in stool microbiota composition. — At day 1 (visit V1) and day 85 (visit 3).","Change in skin microbiota composition. — At day 1 (visit V1) and day 85 (visit 3)."],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"skin-aging","is_published":true,"match_reasons":["Title contains controlled term: skin ageing.","Abstract contains controlled term: skin ageing, photoaging.","Source terminology contains: skin ageing.","Title supplies longevity context: ageing.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Skin ageing","slug":"skin-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/21881","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}