{"type":"trials","record":{"id":21898,"source_id":"clinicaltrials-gov","external_id":"NCT06693271","title":"Investigating the Combined Effects of Protein, Blueberries, and Exercise on Cardiovascular Health and Frailty in Older Nova Scotians","brief_summary":"Cardiovascular diseases (CVD) are a leading cause of morbidity and mortality worldwide. While CVDs are predominantly diseases of aging, age itself does not predict CVD risk; people age at different rates. Frailty is a state of accelerated aging that increases the risk of adverse health outcomes. Frail people are at higher risk of developing CVDs, experiencing complications, and dying from these diseases than fit people of the same age. Indeed, frailty predicts the likelihood of developing CVD independently of traditional risk factors for CVD. It is known that older women are frailer than men and tend to express CVDs differently than men, but whether relationships between frailty and CVD are sex specific is unclear. It is possible that shared pathophysiological mechanisms such as chronic inflammation may help explain links between CVD and frailty. Importantly, the degree of frailty can be modified by lifestyle interventions. For example, sedentary lifestyles, food insecurity, and suboptimal dietary habits can exacerbate frailty whereas diet and exercise interventions can attenuate frailty. The investigators propose that a comprehensive health strategy targeting diet and physical activity to reduce frailty will reduce the risk of cardiovascular disease (CVD), thereby promoting healthy aging. Engaging in physical activity (e.g. exercise) helps improve aerobic fitness, increase muscle mass, promote cardiac regeneration, enhance metabolic function, regulate blood pressure, improve insulin sensitivity, reduce inflammation (a key frailty mechanism), and lessen frailty. High-quality dietary protein is essential to maintain muscle mass/function, preserve mobility, attenuate inflammation, and reduce frailty. Packed with antioxidants such as anthocyanins and flavonoids, with high levels of fiber, vitamins, and minerals, blueberries, a local Nova Scotian food, can help lower blood pressure, improve blood vessel function, reduce inflammation, and help the body utilize dietary protein. These are critical aspects of a strong heart and healthy aging. To date, many frailty intervention studies have been limited by small sample sizes, underrepresentation of women, and/or by testing individual lifestyle modifications rather than synergistic effects; additionally, none have investigated how reducing frailty impacts cardiovascular outcomes. Our goal is to determine if a year-long multidomain intervention of protein, blueberries, and exercise reduces frailty and cardiovascular disease risk in older at-risk Nova Scotians of both sexes.","overall_status":"Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Nova Scotia Health Authority","enrollment":240,"countries":["Canada"],"start_date":"2025-12-15","completion_date":"2028-12-31","last_update_date":"2026-08-28","source_url":"https://clinicaltrials.gov/study/NCT06693271","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:12.439005+00:00","last_seen_at":"2026-09-25T07:05:20.248+00:00","metadata":{"sex":"ALL","acronym":"STRONG","age_range":"65 Years","comparator":"intervention of protein, blueberries, and exercise; Control group","organization":"Nova Scotia Health Authority","interventions":["intervention of protein, blueberries","Exercise training"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Cardiovascular Risk - Echocardiography — Baseline, 12 Months","Inflammatory Markers — Baseline, 12 Months","Frailty — Baseline, 3,6,9, and 12 months","Cardiovascualr Risk: Blood pressure — Baseline, 3, 6, 9, 12 months","Cardiovascualr Risk: Lipid Profile — Baseline, 12 months","Frailty: Clinical Frailty Scale (CFS) — Baseline, 3, 6, 9, 12 months","Frailty: Pictorial Fit to frail Scale (PFFS) — Baseline, 3, 6, 9, 12 months","Muscular Health: Lower Body Strength — Baseline, 3,6,9, and 12 months","Functional Fitness — Baseline, 3,6,9, and 12 months","Balance — Baseline, 3,6,9, and 12 months","Mobility: Lower Body — Baseline, 3,6,9, and 12 months","Overall Health — Baseline, 3,6,9, and 12 months","Muscular Health: Upper Body — Baseline, 3, 6, 9, 12 months","Mobility: Upper Body — Baseline, 3, 6, 9, and 12 months.","Household Foodwork Interactional Assessment 10 Questions (FIA-Q10) — Baseline, 6-month, 12-month, 1 year","ASA24 Dietary Assessment Tool — Baseline, 6-month, 12-month, 1-year."],"design_description":"RANDOMIZED · PARALLEL · PREVENTION · SINGLE","source_has_results":false},"controlled_terms":["Cardiovascular Disease","Frailty","intervention of protein, blueberries","Exercise training"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: exercise.","quality_checked_at":"2026-09-25T07:05:30.295959+00:00","duplicate_cluster_key":"id:nct06693271","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-12-15 to 2028-12-31","comparator":"intervention of protein, blueberries, and exercise; Control group","confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T07:05:20.254Z","intervention":["intervention of protein, blueberries","Exercise training"],"participants":240,"study_design":"RANDOMIZED · PARALLEL · PREVENTION · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Cardiovascular Risk - Echocardiography — Baseline, 12 Months","Inflammatory Markers — Baseline, 12 Months","Frailty — Baseline, 3,6,9, and 12 months","Cardiovascualr Risk: Blood pressure — Baseline, 3, 6, 9, 12 months","Cardiovascualr Risk: Lipid Profile — Baseline, 12 months","Frailty: Clinical Frailty Scale (CFS) — Baseline, 3, 6, 9, 12 months","Frailty: Pictorial Fit to frail Scale (PFFS) — Baseline, 3, 6, 9, 12 months","Muscular Health: Lower Body Strength — Baseline, 3,6,9, and 12 months","Functional Fitness — Baseline, 3,6,9, and 12 months","Balance — Baseline, 3,6,9, and 12 months","Mobility: Lower Body — Baseline, 3,6,9, and 12 months","Overall Health — Baseline, 3,6,9, and 12 months","Muscular Health: Upper Body — Baseline, 3, 6, 9, 12 months","Mobility: Upper Body — Baseline, 3, 6, 9, and 12 months.","Household Foodwork Interactional Assessment 10 Questions (FIA-Q10) — Baseline, 6-month, 12-month, 1 year","ASA24 Dietary Assessment Tool — Baseline, 6-month, 12-month, 1-year."],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"exercise","is_published":true,"match_reasons":["Title contains controlled term: exercise.","Abstract contains controlled term: exercise, physical activity.","Source terminology contains: exercise.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Exercise","slug":"exercise"}},{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Abstract contains controlled term: frailty.","Source terminology contains: frailty.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/21898","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}