{"type":"trials","record":{"id":21918,"source_id":"clinicaltrials-gov","external_id":"NCT07590089","title":"Relationship Between NLRP3 Inflammasome Activation and Stages of Periodontitis: An Association With Inflammaging","brief_summary":"This study aims to investigate the relationship between NLRP3 inflammasome activation and different stages of periodontitis, with a focus on its association with inflammaging. Periodontitis is a chronic inflammatory disease affecting the supporting tissues of the teeth, and aging-related inflammation may influence its progression. The study will include participants with different stages of periodontitis as well as healthy individuals. Clinical periodontal parameters will be recorded, and biological samples such as saliva or gingival crevicular fluid will be collected to measure levels of NLRP3 inflammasome components and inflammatory markers. The results of this study may help improve understanding of the role of inflammation and aging in periodontal disease and could contribute to better diagnosis and treatment strategies.","overall_status":"Completed","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Misr University for Science and Technology","enrollment":80,"countries":["Egypt"],"start_date":"2025-01-01","completion_date":"2026-01-20","last_update_date":"2026-05-15","source_url":"https://clinicaltrials.gov/study/NCT07590089","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:12.439005+00:00","last_seen_at":"2026-09-25T06:25:08.953+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"18 Years","comparator":null,"organization":"Misr University for Science and Technology","interventions":[],"registry_source":"ClinicalTrials.gov","outcome_measures":["Concentration of NLRP3 Inflammasome in Gingival Crevicular Fluid Among Different Stages of Periodontitis — 6 months","RELATCorrelation Between NLRP3 Inflammasome Concentration and Clinical Periodontal ParametersIONSHIP BETWEEN NLRP3 INFL…","Correlation Between Age and NLRP3 Inflammasome Concentration in Gingival Crevicular Fluid — 6 months"],"design_description":null,"source_has_results":false},"controlled_terms":["Periodontitis","Periodontitis Stage I","Periodontitis Stage II","Periodontitis Stage III"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: periodontitis.","quality_checked_at":"2026-09-25T06:25:14.10514+00:00","duplicate_cluster_key":"id:nct07590089","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-01-01 to 2026-01-20","comparator":null,"confidence":"structured-source","population":"ALL · 18 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:25:08.971Z","intervention":[],"participants":80,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Concentration of NLRP3 Inflammasome in Gingival Crevicular Fluid Among Different Stages of Periodontitis — 6 months","RELATCorrelation Between NLRP3 Inflammasome Concentration and Clinical Periodontal ParametersIONSHIP BETWEEN NLRP3 INFL…","Correlation Between Age and NLRP3 Inflammasome Concentration in Gingival Crevicular Fluid — 6 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"chronic-inflammation","is_published":true,"match_reasons":["Title contains controlled term: inflammaging.","Abstract contains controlled term: inflammaging.","Title supplies longevity context: aging.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Chronic inflammation","slug":"chronic-inflammation"}},{"topic_slug":"oral-health-aging","is_published":true,"match_reasons":["Title contains controlled term: periodontitis.","Abstract contains controlled term: periodontitis.","Source terminology contains: periodontitis.","Title supplies longevity context: aging.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Oral health and ageing","slug":"oral-health-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/21918","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}