{"type":"trials","record":{"id":21921,"source_id":"clinicaltrials-gov","external_id":"NCT07563725","title":"Vascular Aging and Microcirculation: Physiological Aspects of Vascular Aging in the Elderly Population (VAMP-Aging)","brief_summary":"Rising life expectancy worldwide challenges public health due to increased cardiovascular disease linked to vascular aging, where microvascular dysfunction serves as an early indicator of system-wide inflammation, or \"inflammaging\". The proposed study aims to validate non-invasive, high-resolution techniques, such as Laser Speckle Contrast Imaging, to identify early endothelial senescence biomarkers and map their correlation with metabolic, inflammatory, and anthropometric profiles to advance personalized, preventive translational medicine.","overall_status":"Not Yet Recruiting","phases":[],"study_type":"OBSERVATIONAL","sponsor":"National Institute of Cardiology, Laranjeiras, Brazil","enrollment":62,"countries":["Brazil"],"start_date":"2026-06-01","completion_date":"2029-12-01","last_update_date":"2026-05-04","source_url":"https://clinicaltrials.gov/study/NCT07563725","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Not Yet Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:12.439005+00:00","last_seen_at":"2026-09-25T06:10:49.917+00:00","metadata":{"sex":"ALL","acronym":"VAMP-Aging","age_range":"60 Years to 100 Years","comparator":null,"organization":"National Institute of Cardiology, Laranjeiras, Brazil","interventions":["Laser Speckle Contrast Imaging","Handgrip Dynamometry (Muscle Strength)","Sit-to-Stand Test (5-Times Sit-to-Stand - 5STS)","Single-Leg Balance Test","Assessment of Global Cognitive Function"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Systemic (cutaneous) microcirculatory reactivity. — up to 20 minutes","Muscle Strength — up to 10 minutes"],"design_description":null,"source_has_results":false},"controlled_terms":["Aging Problems","Laser Speckle Contrast Imaging","Handgrip Dynamometry (Muscle Strength)","Sit-to-Stand Test (5-Times Sit-to-Stand - 5STS)","Single-Leg Balance Test","Assessment of Global Cognitive Function"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: vascular aging.","quality_checked_at":"2026-09-25T06:10:57.79658+00:00","duplicate_cluster_key":"id:nct07563725","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2026-06-01 to 2029-12-01","comparator":null,"confidence":"structured-source","population":"ALL · 60 Years to 100 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:49.925Z","intervention":["Laser Speckle Contrast Imaging","Handgrip Dynamometry (Muscle Strength)","Sit-to-Stand Test (5-Times Sit-to-Stand - 5STS)","Single-Leg Balance Test","Assessment of Global Cognitive Function"],"participants":62,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Systemic (cutaneous) microcirculatory reactivity. — up to 20 minutes","Muscle Strength — up to 10 minutes"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"cardiovascular-aging","is_published":true,"match_reasons":["Title contains controlled term: vascular aging.","Abstract contains controlled term: vascular aging.","Title supplies longevity context: aging, elderly.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Cardiovascular ageing","slug":"cardiovascular-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/21921","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}