{"type":"trials","record":{"id":21934,"source_id":"clinicaltrials-gov","external_id":"NCT05625204","title":"High Intensity Interval Training (HIIT) to Reduce Frailty and Enhance Resilience in Older Veterans","brief_summary":"Frailty is defined as a greater susceptibility to stressors resulting from age-related impairments in adaptive biological systems. Frailty leads to poorer physical performance and functional capacity and higher risk of adverse outcomes including falls, hospitalization, and mortality. Resilience, defined as the capacity to recover from disruptions to homeostasis, is critical to successful aging because it precedes frailty and enhances adults' ability to maintain optimal health and function well into older age. Evidence- based therapies to help older adults enhance resilience are limited and the biological underpinnings contributing to improved resilience have not yet been fully characterized. To address this important need, the investigators will conduct a clinical trial to examine the benefits of center- and home-based high intensity interval training (HIIT) on functional capacity, frailty, and resilience, and also to identify novel biomarkers of resilience in older Veterans.","overall_status":"Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"VA Office of Research and Development","enrollment":200,"countries":["United States"],"start_date":"2024-01-29","completion_date":"2027-09-30","last_update_date":"2025-12-12","source_url":"https://clinicaltrials.gov/study/NCT05625204","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:12.439005+00:00","last_seen_at":"2026-09-25T07:05:20.248+00:00","metadata":{"sex":"ALL","acronym":"HIIT@Home","age_range":"65 Years","comparator":null,"organization":"VA Office of Research and Development","interventions":["Center based attention (stretching only) control","Center based HIIT","Home based HIIT"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Sub-maximal oxygen uptake test (VO2max) — Change from baseline to endpoint at 12 weeks","Cognitive screen - SLUMS — Change from baseline to endpoint at 12 weeks","Amyloid beta 42/40 ratio — Change from baseline to endpoint at 12 weeks","Cognitive screen - Cognivue — Change from baseline to endpoint at 12 weeks","Phosphorylated tau (P-tau) — Change from baseline to endpoint at 12 weeks","Brain Derived Neurotrophic Factor (BDNF) — Change from baseline to endpoint at 12 weeks","Fatigue — Change from baseline to endpoint at 12 weeks","Sleep quantity and stages — Change from baseline to endpoint at 12 weeks","Sleep quality — Change from baseline to endpoint at 12 weeks","Sleep chronotype — Change from baseline to endpoint at 12 weeks","Sleepiness — Change from baseline to endpoint at 12 weeks","Insomnia — Change from baseline to endpoint at 12 weeks","Anxiety and depression — Change from baseline to endpoint at 12 weeks","Sleep disorders — Change from baseline to endpoint at 12 weeks","30 second chair rise test — Change from baseline to endpoint at 12 weeks","Frailty assessment — Change from baseline to endpoint at 12 weeks","Gait speed — Change from baseline to endpoint at 12 weeks","Arm curl endurance — Change from baseline to endpoint at 12 weeks","Quality of life assessment — Change from baseline to endpoint at 12 weeks","Body Composition (Lean and fat mass) — Change from baseline to endpoint at 12 weeks"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · NONE","source_has_results":false},"controlled_terms":["Frailty","Center based attention (stretching only) control","Center based HIIT","Home based HIIT"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":85,"publication_state":"published","match_explanation":"Title contains controlled term: frailty.","quality_checked_at":"2026-09-25T07:05:30.295959+00:00","duplicate_cluster_key":"id:nct05625204","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2024-01-29 to 2027-09-30","comparator":null,"confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T07:05:20.291Z","intervention":["Center based attention (stretching only) control","Center based HIIT","Home based HIIT"],"participants":200,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Sub-maximal oxygen uptake test (VO2max) — Change from baseline to endpoint at 12 weeks","Cognitive screen - SLUMS — Change from baseline to endpoint at 12 weeks","Amyloid beta 42/40 ratio — Change from baseline to endpoint at 12 weeks","Cognitive screen - Cognivue — Change from baseline to endpoint at 12 weeks","Phosphorylated tau (P-tau) — Change from baseline to endpoint at 12 weeks","Brain Derived Neurotrophic Factor (BDNF) — Change from baseline to endpoint at 12 weeks","Fatigue — Change from baseline to endpoint at 12 weeks","Sleep quantity and stages — Change from baseline to endpoint at 12 weeks","Sleep quality — Change from baseline to endpoint at 12 weeks","Sleep chronotype — Change from baseline to endpoint at 12 weeks","Sleepiness — Change from baseline to endpoint at 12 weeks","Insomnia — Change from baseline to endpoint at 12 weeks","Anxiety and depression — Change from baseline to endpoint at 12 weeks","Sleep disorders — Change from baseline to endpoint at 12 weeks","30 second chair rise test — Change from baseline to endpoint at 12 weeks","Frailty assessment — Change from baseline to endpoint at 12 weeks","Gait speed — Change from baseline to endpoint at 12 weeks","Arm curl endurance — Change from baseline to endpoint at 12 weeks","Quality of life assessment — Change from baseline to endpoint at 12 weeks","Body Composition (Lean and fat mass) — Change from baseline to endpoint at 12 weeks"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Abstract contains controlled term: frailty.","Source terminology contains: frailty.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/21934","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}