{"type":"trials","record":{"id":21966,"source_id":"clinicaltrials-gov","external_id":"NCT07500727","title":"Skeletal Muscle Aging and Responsiveness in Aged People With MS","brief_summary":"The purposes of this study are to: 1) compare baseline muscle and cardiovascular health in older individuals (\\>60 years old) diagnosed with MS to age-matched people without MS, 2) determine muscle and whole body changes to an exercise training program, 3) determine if the muscle in a more affected leg in individuals diagnosed with MS is different from the muscle of a less affected leg, and 4) if or how individuals diagnosed with MS adapt differently than age-matched people without MS to exercise training. Participation in this study will average 1.5 hours per visit, 3 visits per week, for approximately 4 months.","overall_status":"Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Oklahoma Medical Research Foundation","enrollment":10,"countries":["United States"],"start_date":"2026-03-06","completion_date":"2026-12-31","last_update_date":"2026-03-30","source_url":"https://clinicaltrials.gov/study/NCT07500727","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:13.078566+00:00","last_seen_at":"2026-09-25T06:25:39.067+00:00","metadata":{"sex":"ALL","acronym":"MS-M3AX","age_range":"60 Years","comparator":null,"organization":"Oklahoma Medical Research Foundation","interventions":["Exercise trial consisting of both cardiovascular and strength training"],"registry_source":"ClinicalTrials.gov","outcome_measures":["fMQ — Week -3 and Week -2","CRF — Enrollment to end of study at 18 weeks","Total and Regional Body Composition — Week -3 and Week -2","Muscle Biopsy — Week 1 and Week 12 Muscle Biopsy","Skeletal Muscle Phenotyping — Week 0, 6, and 12","Systemic Inflammation — Week 1 and Week 12","Muscle Inflammation — Week 1 and Week 12","Blood Biomarkers — Week 1 and Week 12","Mobility and Balance — Week -3 and Week -2","Basic Cognitive Function and Balance — Week -3 and Week -2","Participant's Self Evaluation of Physical, Mental, and Social Health — Week -3 and Week -2","Depression — Week -3 and Week -2","Circadian Rhythm — Week -3 and Week -2","Sleep Quality — Week -3 and Week -2","Fatigue — Week -3 and Week -2","Gait Speed — Week -3 and Week -2","Functional Capacity — Week -3 and Week -2","Phenotyping Support with Multidimensional Interindividual Response Heterogeneity — Week 1 through Week 13","Glucose Monitoring — Week 1 and Week 12","Dietary Intake — Week -3 to -2, Week 0, Week 6, and Week 12"],"design_description":"NA · SINGLE GROUP · OTHER · NONE","source_has_results":false},"controlled_terms":["Multiple Sclerosis","Aging","Exercise trial consisting of both cardiovascular and strength training"],"relevance_confidence":80,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: muscle aging.","quality_checked_at":"2026-09-25T06:25:42.287439+00:00","duplicate_cluster_key":"id:nct07500727","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2026-03-06 to 2026-12-31","comparator":null,"confidence":"structured-source","population":"ALL · 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:25:39.087Z","intervention":["Exercise trial consisting of both cardiovascular and strength training"],"participants":10,"study_design":"NA · SINGLE GROUP · OTHER · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["fMQ — Week -3 and Week -2","CRF — Enrollment to end of study at 18 weeks","Total and Regional Body Composition — Week -3 and Week -2","Muscle Biopsy — Week 1 and Week 12 Muscle Biopsy","Skeletal Muscle Phenotyping — Week 0, 6, and 12","Systemic Inflammation — Week 1 and Week 12","Muscle Inflammation — Week 1 and Week 12","Blood Biomarkers — Week 1 and Week 12","Mobility and Balance — Week -3 and Week -2","Basic Cognitive Function and Balance — Week -3 and Week -2","Participant's Self Evaluation of Physical, Mental, and Social Health — Week -3 and Week -2","Depression — Week -3 and Week -2","Circadian Rhythm — Week -3 and Week -2","Sleep Quality — Week -3 and Week -2","Fatigue — Week -3 and Week -2","Gait Speed — Week -3 and Week -2","Functional Capacity — Week -3 and Week -2","Phenotyping Support with Multidimensional Interindividual Response Heterogeneity — Week 1 through Week 13","Glucose Monitoring — Week 1 and Week 12","Dietary Intake — Week -3 to -2, Week 0, Week 6, and Week 12"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"sarcopenia","is_published":true,"match_reasons":["Title contains controlled term: muscle aging.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Sarcopenia","slug":"sarcopenia"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/21966","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}