{"type":"trials","record":{"id":21992,"source_id":"clinicaltrials-gov","external_id":"NCT02953093","title":"Study of Acarbose in Longevity","brief_summary":"The investigators are studying the effects of acarbose on muscle and adipose gene transcription in older adults.","overall_status":"Terminated","phases":["PHASE2"],"study_type":"INTERVENTIONAL","sponsor":"Montefiore Medical Center","enrollment":28,"countries":["United States"],"start_date":"2017-08-30","completion_date":"2019-12-26","last_update_date":"2025-06-24","source_url":"https://clinicaltrials.gov/study/NCT02953093","editorial_summary":"A registered PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Terminated. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:13.475905+00:00","last_seen_at":"2026-09-25T06:15:12.989+00:00","metadata":{"sex":"MALE","acronym":"SAIL","age_range":"60 Years to 100 Years","comparator":null,"organization":"Montefiore Medical Center","interventions":["Acarbose","Placebo"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Tissue Gene Expression Using RNA Sequencing (RNA-Seq) — 10 weeks","Serum microRNA (miRNA) — At the end of 10 week treatment period (Visit 4) and at 22 weeks (Visit 6) following enrollment","Fecal Microbiome for 16s Ribosomal DNA (rDNA) Gene Sequencing — At the end of 10 week treatment period (Visit 4) and at…"],"design_description":"RANDOMIZED · CROSSOVER · TREATMENT · QUADRUPLE","source_has_results":true},"controlled_terms":["Aging","Acarbose","Placebo"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: acarbose.","quality_checked_at":"2026-09-25T06:15:13.224785+00:00","duplicate_cluster_key":"id:nct02953093","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2017-08-30 to 2019-12-26","comparator":null,"confidence":"structured-source","population":"MALE · 60 Years to 100 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:12.991Z","intervention":["Acarbose","Placebo"],"participants":28,"study_design":"RANDOMIZED · CROSSOVER · TREATMENT · QUADRUPLE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE2","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Tissue Gene Expression Using RNA Sequencing (RNA-Seq) — 10 weeks","Serum microRNA (miRNA) — At the end of 10 week treatment period (Visit 4) and at 22 weeks (Visit 6) following enrollment","Fecal Microbiome for 16s Ribosomal DNA (rDNA) Gene Sequencing — At the end of 10 week treatment period (Visit 4) and at…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"acarbose","is_published":true,"match_reasons":["Title contains controlled term: acarbose.","Abstract contains controlled term: acarbose.","Source terminology contains: acarbose.","Title supplies longevity context: longevity.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Acarbose","slug":"acarbose"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/21992","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}