{"type":"trials","record":{"id":21994,"source_id":"clinicaltrials-gov","external_id":"NCT01914133","title":"Acarbose and Older Adults With Postprandial Hypotension","brief_summary":"The current proposal will determine if blocking carbohydrate intake in the small intestine with Acarbose can be a possible therapy for older adults with (PPH) Post Prandial Hypotension (a drop of blood pressure after eating), which can result in falls.","overall_status":"Completed","phases":["PHASE2"],"study_type":"INTERVENTIONAL","sponsor":"Kenneth Madden","enrollment":42,"countries":["Canada"],"start_date":"2014-01-01","completion_date":"2021-05-01","last_update_date":"2021-05-28","source_url":"https://clinicaltrials.gov/study/NCT01914133","editorial_summary":"A registered PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:13.475905+00:00","last_seen_at":"2026-09-25T06:05:54.424+00:00","metadata":{"sex":"ALL","acronym":"PPH","age_range":"65 Years","comparator":"No Postprandial Hypotension (PPH); Placebo; Acarbose","organization":"University of British Columbia","interventions":["Acarbose","Placebo"],"registry_source":"ClinicalTrials.gov","outcome_measures":["The postprandial cardiovascular response to a standardized meal compared between subjects with and without PPH — 2 years","The postprandial glucagon-like peptide-1 (GLP-1) and gastric inhibitory peptide (GIP) response to a standardized meal c…","The postprandial cardiovascular response between the Acarbose group and the Placebo group will be compared. — 2.5 years"],"design_description":"RANDOMIZED · FACTORIAL · TREATMENT · QUADRUPLE","source_has_results":false},"controlled_terms":["Other Specified Hypotension","Syncope","Acarbose","Placebo"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: acarbose.","quality_checked_at":"2026-09-25T06:05:54.569767+00:00","duplicate_cluster_key":"id:nct01914133","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2014-01-01 to 2021-05-01","comparator":"No Postprandial Hypotension (PPH); Placebo; Acarbose","confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:05:54.425Z","intervention":["Acarbose","Placebo"],"participants":42,"study_design":"RANDOMIZED · FACTORIAL · TREATMENT · QUADRUPLE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE2","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["The postprandial cardiovascular response to a standardized meal compared between subjects with and without PPH — 2 years","The postprandial glucagon-like peptide-1 (GLP-1) and gastric inhibitory peptide (GIP) response to a standardized meal c…","The postprandial cardiovascular response between the Acarbose group and the Placebo group will be compared. — 2.5 years"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"acarbose","is_published":true,"match_reasons":["Title contains controlled term: acarbose.","Abstract contains controlled term: acarbose.","Source terminology contains: acarbose.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Acarbose","slug":"acarbose"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/21994","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}