{"type":"trials","record":{"id":21996,"source_id":"clinicaltrials-gov","external_id":"NCT02865499","title":"Acarbose Anti-aging Effects in Geriatric Subjects (Substudy B & C)","brief_summary":"This study addresses a \"lifespan approach to healthy development and aging\" with direct relevance to humans by testing the anti-aging effects of acarbose in humans. It is a pilot study to: i) better estimate power for a larger trial, ii) establish the safety and potential beneficial effects of acarbose in non-diabetic elderly humans, and iii) determine whether the effects of acarbose on the microbiome likely play a role in its enhancement of longevity and/or healthy aging. These are essential initial steps for translating acarbose into an anti-aging human therapy.","overall_status":"Completed","phases":["PHASE2"],"study_type":"INTERVENTIONAL","sponsor":"The University of Texas Health Science Center at San Antonio","enrollment":8,"countries":["United States"],"start_date":"2016-06-01","completion_date":"2017-10-01","last_update_date":"2019-03-14","source_url":"https://clinicaltrials.gov/study/NCT02865499","editorial_summary":"A registered PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:13.475905+00:00","last_seen_at":"2026-09-25T06:05:54.424+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"70 Years to 95 Years","comparator":null,"organization":"The University of Texas Health Science Center at San Antonio","interventions":["acarbose"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in Microbiome — Baseline; 8 weeks and 12 weeks"],"design_description":"NA · SINGLE GROUP · PREVENTION · NONE","source_has_results":true},"controlled_terms":["Aging","acarbose"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: acarbose.","quality_checked_at":"2026-09-25T06:05:54.569767+00:00","duplicate_cluster_key":"id:nct02865499","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2016-06-01 to 2017-10-01","comparator":null,"confidence":"structured-source","population":"ALL · 70 Years to 95 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:05:54.425Z","intervention":["acarbose"],"participants":8,"study_design":"NA · SINGLE GROUP · PREVENTION · NONE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE2","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in Microbiome — Baseline; 8 weeks and 12 weeks"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"acarbose","is_published":true,"match_reasons":["Title contains controlled term: acarbose.","Abstract contains controlled term: acarbose.","Source terminology contains: acarbose.","Title supplies longevity context: aging, geriatric.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Acarbose","slug":"acarbose"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/21996","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}