{"type":"trials","record":{"id":22001,"source_id":"clinicaltrials-gov","external_id":"NCT07269704","title":"Effect of Nutritional Supplement Alpha-ketoglutarate for Age-related Ocular Disease","brief_summary":"The aims of the study are as follows: 1. Determine how the eye absorbs supplements taken orally. 2. Look for specific signs in the proteins and substances in the eyes of people with eye diseases who are also taking nutritional supplements.","overall_status":"Completed","phases":["EARLY_PHASE1"],"study_type":"INTERVENTIONAL","sponsor":"Stanford University","enrollment":17,"countries":["United States"],"start_date":"2023-08-15","completion_date":"2025-06-10","last_update_date":"2026-04-03","source_url":"https://clinicaltrials.gov/study/NCT07269704","editorial_summary":"A registered EARLY_PHASE1 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:13.793658+00:00","last_seen_at":"2026-09-25T06:05:53.992+00:00","metadata":{"sex":"ALL","acronym":"OAK AGE","age_range":"18 Years","comparator":null,"organization":"Stanford University","interventions":["Calcium alpha-ketoglutarate"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Mean change in aqueous humor aKG level — Baseline and post-supplementation, approximately 28 days","Mean fold-change in metabolic and retinal pathways — Baseline and post-supplementation, approximately 28 days"],"design_description":"NA · SINGLE GROUP · PREVENTION · NONE","source_has_results":false},"controlled_terms":["Eye Diseases","Calcium alpha-ketoglutarate"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: alpha-ketoglutarate.","quality_checked_at":"2026-09-25T06:05:54.13827+00:00","duplicate_cluster_key":"id:nct07269704","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2023-08-15 to 2025-06-10","comparator":null,"confidence":"structured-source","population":"ALL · 18 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:05:53.993Z","intervention":["Calcium alpha-ketoglutarate"],"participants":17,"study_design":"NA · SINGLE GROUP · PREVENTION · NONE","subject_scope":"Human clinical study registration","evidence_stage":"EARLY_PHASE1","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Mean change in aqueous humor aKG level — Baseline and post-supplementation, approximately 28 days","Mean fold-change in metabolic and retinal pathways — Baseline and post-supplementation, approximately 28 days"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"alpha-ketoglutarate","is_published":true,"match_reasons":["Title contains controlled term: alpha-ketoglutarate.","Source terminology contains: alpha-ketoglutarate.","Title supplies longevity context: age-related.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Alpha-ketoglutarate","slug":"alpha-ketoglutarate"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/22001","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}