{"type":"trials","record":{"id":22074,"source_id":"clinicaltrials-gov","external_id":"NCT04241159","title":"Study to Explore the Safety and Feasibility of Allogeneic Young Plasma Infusion in Older Adults","brief_summary":"Evaluate the feasibility of administering plasma (PF24) acquired from donors of a young chronological age intravenously to older adults at WFBMC while also exploring its effects on age-related functional decline","overall_status":"Withdrawn","phases":["EARLY_PHASE1"],"study_type":"INTERVENTIONAL","sponsor":"Wake Forest University Health Sciences","enrollment":0,"countries":["United States"],"start_date":"2020-05-01","completion_date":"2020-08-01","last_update_date":"2020-05-22","source_url":"https://clinicaltrials.gov/study/NCT04241159","editorial_summary":"A registered EARLY_PHASE1 study indexed because it matched monitored longevity research terms. Registry status: Withdrawn. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:15.326805+00:00","last_seen_at":"2026-09-25T06:10:04.076+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"65 Years to 80 Years","comparator":null,"organization":"Wake Forest University Health Sciences","interventions":["Allogeneic Young Plasma"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Frequency of adverse events — Post 5 weeks after the last infusion of plasma","Study participant retention — Post 5 weeks after the last infusion of plasma","Study participants ability to complete the Fried Frailty Assessment — Study endpoint weeks 11 and 15"],"design_description":"NON RANDOMIZED · PARALLEL · SUPPORTIVE CARE · NONE","source_has_results":false},"controlled_terms":["Frailty Syndrome","Heart Failure","Allogeneic Young Plasma"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: young plasma.","quality_checked_at":"2026-09-25T06:10:04.34505+00:00","duplicate_cluster_key":"id:nct04241159","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2020-05-01 to 2020-08-01","comparator":null,"confidence":"structured-source","population":"ALL · 65 Years to 80 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:04.076Z","intervention":["Allogeneic Young Plasma"],"participants":0,"study_design":"NON RANDOMIZED · PARALLEL · SUPPORTIVE CARE · NONE","subject_scope":"Human clinical study registration","evidence_stage":"EARLY_PHASE1","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Frequency of adverse events — Post 5 weeks after the last infusion of plasma","Study participant retention — Post 5 weeks after the last infusion of plasma","Study participants ability to complete the Fried Frailty Assessment — Study endpoint weeks 11 and 15"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"young-blood-parabiosis","is_published":true,"match_reasons":["Title contains controlled term: young plasma.","Source terminology contains: young plasma.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Young blood and parabiosis","slug":"young-blood-parabiosis"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/22074","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}