{"type":"trials","record":{"id":22128,"source_id":"clinicaltrials-gov","external_id":"NCT07837219","title":"Frailty and Outcomes in Critically Ill Patients Receiving Continuous Renal Replacement Therapy: A Nationwide Swedish Cohort Study","brief_summary":"This nationwide observational cohort study will investigate the association between frailty, chronological age, and clinical outcomes in critically ill patients receiving continuous renal replacement therapy (CRRT) in Sweden. Using data from the Swedish Intensive Care Registry, the study will assess whether the Clinical Frailty Scale (CFS) and other measures of comorbidity and illness severity provide prognostic information beyond chronological age. Outcomes will include 30-day mortality, intensive care unit length of stay, and mortality at 60, 90, and 365 days following ICU admission. The study aims to contribute to more individualized assessment of critically ill patients who may require CRRT.","overall_status":"Not Yet Recruiting","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Karolinska Institutet","enrollment":22000,"countries":[],"start_date":"2026-11-01","completion_date":"2028-12-31","last_update_date":"2026-09-23","source_url":"https://clinicaltrials.gov/study/NCT07837219","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Not Yet Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:16.301579+00:00","last_seen_at":"2026-09-25T06:10:07.378+00:00","metadata":{"sex":"ALL","acronym":"CRRT-AF","age_range":"18 Years","comparator":null,"organization":"Karolinska Institutet","interventions":[],"registry_source":"ClinicalTrials.gov","outcome_measures":["30-day mortality — Within 30 days after ICU admission.","Intensive care unit length of stay — During the index ICU admission.","60-day mortality — Within 60 days after ICU admission.","90-day mortality — Within 90 days after ICU admission.","365-day mortality — Within 365 days after ICU admission."],"design_description":null,"source_has_results":false},"controlled_terms":["Acute Kidney Injury"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: frailty.","quality_checked_at":"2026-09-25T06:10:20.034853+00:00","duplicate_cluster_key":"id:nct07837219","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2026-11-01 to 2028-12-31","comparator":null,"confidence":"structured-source","population":"ALL · 18 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:07.379Z","intervention":[],"participants":22000,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["30-day mortality — Within 30 days after ICU admission.","Intensive care unit length of stay — During the index ICU admission.","60-day mortality — Within 60 days after ICU admission.","90-day mortality — Within 90 days after ICU admission.","365-day mortality — Within 365 days after ICU admission."],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Abstract contains controlled term: frailty.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/22128","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}