{"type":"trials","record":{"id":22149,"source_id":"clinicaltrials-gov","external_id":"NCT07826052","title":"Chemotherapy Exemption in Elderly Women With Node-Positive ER+/HER2- Breast Cancer","brief_summary":"This study is a prospective, open-label, multicenter, single-arm Phase II clinical trial. Based on the use of CDK4/6 inhibitors in endocrine-sensitive luminal-type (ER+/HER2-) breast cancer, it aims to explore the possibility of chemotherapy exemption in elderly patients (aged \\>65 years) with lymph node-positive, HR+/HER2- breast cancer.","overall_status":"Not Yet Recruiting","phases":["PHASE2"],"study_type":"INTERVENTIONAL","sponsor":"Fudan University","enrollment":494,"countries":[],"start_date":"2026-09-15","completion_date":"2035-10-01","last_update_date":"2026-09-17","source_url":"https://clinicaltrials.gov/study/NCT07826052","editorial_summary":"A registered PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Not Yet Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:16.301579+00:00","last_seen_at":"2026-09-25T06:10:07.378+00:00","metadata":{"sex":"FEMALE","acronym":"ELDER","age_range":"65 Years","comparator":null,"organization":"Fudan University","interventions":["CDK4/6 inhibitor","Endocrine Therapy (Optional)"],"registry_source":"ClinicalTrials.gov","outcome_measures":["5-years Invasive disease free survival — 5 years","Overall Survival (OS) — Approximately 5 years","Safety including adverse events (AEs), severe adverse events (SAEs) and adverse events of special interest (AESI). — Up…","Geriatric assessment (G-8) — Up to approximately 3 years","Clinical Frailty Scale — Up to approximately 3 years"],"design_description":"NA · SINGLE GROUP · TREATMENT · NONE","source_has_results":false},"controlled_terms":["Breast Cancer","Adjuvant Therapy","CDK4/6 inhibitor","Endocrine Therapy (Optional)"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: cancer.","quality_checked_at":"2026-09-25T06:10:20.034853+00:00","duplicate_cluster_key":"id:nct07826052","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2026-09-15 to 2035-10-01","comparator":null,"confidence":"structured-source","population":"FEMALE · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:07.383Z","intervention":["CDK4/6 inhibitor","Endocrine Therapy (Optional)"],"participants":494,"study_design":"NA · SINGLE GROUP · TREATMENT · NONE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE2","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["5-years Invasive disease free survival — 5 years","Overall Survival (OS) — Approximately 5 years","Safety including adverse events (AEs), severe adverse events (SAEs) and adverse events of special interest (AESI). — Up…","Geriatric assessment (G-8) — Up to approximately 3 years","Clinical Frailty Scale — Up to approximately 3 years"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"cancer-and-aging","is_published":true,"match_reasons":["Title contains controlled term: cancer.","Abstract contains controlled term: cancer.","Source terminology contains: cancer.","Title supplies longevity context: elderly.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Cancer and ageing","slug":"cancer-and-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/22149","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}