{"type":"trials","record":{"id":22208,"source_id":"clinicaltrials-gov","external_id":"NCT07562698","title":"Ursolic Acid-Standardized Apple Pomace Supplementation for Muscle Strength and Physical Performance in Older Adults With Mild Sarcopenia: A Randomized, Double-Blind, Placebo-Controlled Trial","brief_summary":"Sarcopenia is an age-related condition characterized by loss of muscle strength and physical performance, leading to increased risk of falls and disability. This randomized, double-blind, placebo-controlled clinical trial aims to evaluate the effects of ursolic acid-standardized apple pomace supplementation on muscle strength and physical performance in older adults with mild sarcopenia. Participants will be randomly assigned to receive either 200 mg/day, 400 mg/day of the supplement, or placebo for 12 weeks. The primary outcome is change in handgrip strength, with additional assessments of physical performance, body composition, fatigue, and quality of life. The study will also evaluate the safety and tolerability of the intervention.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Liaquat University of Medical & Health Sciences","enrollment":105,"countries":["Pakistan"],"start_date":"2026-05-10","completion_date":"2026-08-31","last_update_date":"2026-09-02","source_url":"https://clinicaltrials.gov/study/NCT07562698","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:16.887272+00:00","last_seen_at":"2026-09-25T06:10:25.747+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"65 Years to 80 Years","comparator":"Placebo","organization":"Liaquat University of Medical & Health Sciences","interventions":["Ursolic Acid-Standardized Apple Pomace Extract","Placebo"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in handgrip strength from baseline — Baseline to Week 12","Change in five-times chair stand test time — Baseline to Week 12","Change in Short Physical Performance Battery (SPPB) score — Baseline to Week 12","Change in gait speed — Baseline to Week 12","Change in Timed Up and Go test time — Baseline to Week 12","Change in body composition — Baseline to Week 12","Change in fatigue severity — Baseline to Week 12","Change in health-related quality of life — Baseline to Week 12"],"design_description":"RANDOMIZED · PARALLEL · SUPPORTIVE CARE · QUADRUPLE","source_has_results":false},"controlled_terms":["Sarcopenia","Ursolic Acid-Standardized Apple Pomace Extract","Placebo"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: sarcopenia.","quality_checked_at":"2026-09-25T06:10:37.875473+00:00","duplicate_cluster_key":"id:nct07562698","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2026-05-10 to 2026-08-31","comparator":"Placebo","confidence":"structured-source","population":"ALL · 65 Years to 80 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:25.755Z","intervention":["Ursolic Acid-Standardized Apple Pomace Extract","Placebo"],"participants":105,"study_design":"RANDOMIZED · PARALLEL · SUPPORTIVE CARE · QUADRUPLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in handgrip strength from baseline — Baseline to Week 12","Change in five-times chair stand test time — Baseline to Week 12","Change in Short Physical Performance Battery (SPPB) score — Baseline to Week 12","Change in gait speed — Baseline to Week 12","Change in Timed Up and Go test time — Baseline to Week 12","Change in body composition — Baseline to Week 12","Change in fatigue severity — Baseline to Week 12","Change in health-related quality of life — Baseline to Week 12"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"sarcopenia","is_published":true,"match_reasons":["Title contains controlled term: sarcopenia.","Abstract contains controlled term: sarcopenia.","Source terminology contains: sarcopenia.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Sarcopenia","slug":"sarcopenia"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/22208","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}