{"type":"trials","record":{"id":22217,"source_id":"clinicaltrials-gov","external_id":"NCT07441343","title":"Effects of Polyphenol Supplementation and Exercise on Physical Performance in Older Adults","brief_summary":"After approximately age 40 years, individuals experience a natural loss of muscle mass, strength, and physical function that is linked to higher risks of falls, disability, loss of independence, and mortality. These losses can also be a precursor to the development of frailty, which includes factors beyond impaired physical function such as cognitive impairment, psychological disorder, increased likelihood of hospitalization, need of long term-care, and mortality. Structured exercise-encompassing both resistance and aerobic training-is widely recognized as an effective lifestyle intervention for improving muscle health, cardiovascular capacity, and overall physical function in older adults. However, aging is accompanied by chronically elevated systemic inflammation, and although exercise remains highly beneficial, older adults exhibit a heightened inflammatory response to training and a diminished capacity for post-exercise recovery. Polyphenols, a group of naturally occurring bioactive compounds, have been shown to possess both anti-inflammatory and antioxidant benefits, positively impacting recovery and health. Polyphenol supplementation, particularly when paired with structured exercise, may elicit synergistic improvements in physical performance through combined effects on oxidative stress, inflammation, and muscle recovery, making polyphenols a compelling adjunct strategy for mitigating sarcopenia. In pursuit of refining strategies that support healthy aging and preserve functional capacity in older adults, this study aimed to determine the feasibility of implementing a 12-week resistance and aerobic exercise program combined with dietary supplementation in older adults. Participants will either consume a polyphenol blend or a placebo control of maltodextrin daily whilst undergoing 12 weeks of supervised resistance and aerobic exercise. Additionally, this study will test the hypothesis that polyphenol supplementation will augment the exercise-induced improvements in physical function and muscle health. Further, exploratory analyses of skeletal muscle biopsy and venous plasma samples will aid in elucidating the potential geroprotective effects of polyphenols at both cellular and molecular levels.","overall_status":"Active Not Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Dr. Chris McGlory, PhD","enrollment":40,"countries":["Canada"],"start_date":"2025-09-01","completion_date":"2027-06-08","last_update_date":"2026-08-27","source_url":"https://clinicaltrials.gov/study/NCT07441343","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Active Not Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:16.887272+00:00","last_seen_at":"2026-09-25T06:15:54.38+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"60 Years","comparator":"Placebo Control + Exercise","organization":"Queen's University","interventions":["Polyphenol Rich-Extract","Maltodextrin (Placebo)","Resistance Band-Based & Aerobic Stationary Cycling Exercise"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Feasibility of Retention — 18 months, 12 weeks","Feasibility of Recruitment — 18 months","Leg Extensor Strength — -1 week, 6 weeks, 12 weeks","Leg Exetensor Power — -1 week, 6 weeks, 12 weeks","Handgrip Strength — week -1, week 6, week 12","Aerobic Capacity — -1 week, 6 weeks, 12 weeks","Physical Function 30-Second Sit-to-Stand Test — -1 week, 6 weeks, 12 weeks","Physical Function Short Performance Physical Battery — Time Frame: -1 week, 12 weeks","Physical Function Stair Climb Test — week -1, week 12","Physical Function Functional Forward Reach Test — week -1, week 12","Mitochondrial respiration — -1 week, 12 weeks","Frailty — -1 week, 6 weeks, and 12 weeks","Well-Being — -1 week, 6 weeks, 12 weeks","Anthropometrics Body Height — -1 week, 6 weeks, 12 weeks","Anthropometrics Body Weight — -1 week, 6 weeks, 12 weeks","Body Composition Fat Free Mass — -1 week, 6 weeks, 12 weeks","Body Composition Body Fat Percentage — week -1, week 6, week 12"],"design_description":"RANDOMIZED · PARALLEL · BASIC SCIENCE · TRIPLE","source_has_results":false},"controlled_terms":["Sarcopenia","Aging","Frailty","Polyphenol Rich-Extract","Maltodextrin (Placebo)","Resistance Band-Based & Aerobic Stationary Cycling Exercise"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: exercise.","quality_checked_at":"2026-09-25T06:16:07.48358+00:00","duplicate_cluster_key":"id:nct07441343","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-09-01 to 2027-06-08","comparator":"Placebo Control + Exercise","confidence":"structured-source","population":"ALL · 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:54.391Z","intervention":["Polyphenol Rich-Extract","Maltodextrin (Placebo)","Resistance Band-Based & Aerobic Stationary Cycling Exercise"],"participants":40,"study_design":"RANDOMIZED · PARALLEL · BASIC SCIENCE · TRIPLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Feasibility of Retention — 18 months, 12 weeks","Feasibility of Recruitment — 18 months","Leg Extensor Strength — -1 week, 6 weeks, 12 weeks","Leg Exetensor Power — -1 week, 6 weeks, 12 weeks","Handgrip Strength — week -1, week 6, week 12","Aerobic Capacity — -1 week, 6 weeks, 12 weeks","Physical Function 30-Second Sit-to-Stand Test — -1 week, 6 weeks, 12 weeks","Physical Function Short Performance Physical Battery — Time Frame: -1 week, 12 weeks","Physical Function Stair Climb Test — week -1, week 12","Physical Function Functional Forward Reach Test — week -1, week 12","Mitochondrial respiration — -1 week, 12 weeks","Frailty — -1 week, 6 weeks, and 12 weeks","Well-Being — -1 week, 6 weeks, 12 weeks","Anthropometrics Body Height — -1 week, 6 weeks, 12 weeks","Anthropometrics Body Weight — -1 week, 6 weeks, 12 weeks","Body Composition Fat Free Mass — -1 week, 6 weeks, 12 weeks","Body Composition Body Fat Percentage — week -1, week 6, week 12"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"exercise","is_published":true,"match_reasons":["Title contains controlled term: exercise.","Abstract contains controlled term: exercise.","Source terminology contains: exercise.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Exercise","slug":"exercise"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/22217","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}