{"type":"trials","record":{"id":22253,"source_id":"clinicaltrials-gov","external_id":"NCT05138263","title":"Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer's disease2 (KBASE2)","brief_summary":"The KBASE2 is the second phase of the KBASE project, which consists of roll-over participants from the first phase of the KBASE as well as newly enrolled participants with varying degrees of cognitive functions (e.g. individuals with normal cognition, mild cognitive impairment, or AD dementia). In addition to the aims of the first phase of the KBASE, the KBASE2 will focus on new data collection and integrative analysis of the rich structural, functional, and molecular neuroimaging data in relation to whole genome sequencing and other -omics. Network analysis of disruption in brain connectivity in relation to clinical status and AD biomarker profiles also will be conducted.","overall_status":"Active Not Recruiting","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Seoul National University Hospital","enrollment":640,"countries":["South Korea"],"start_date":"2022-01-01","completion_date":"2027-09-01","last_update_date":"2026-05-27","source_url":"https://clinicaltrials.gov/study/NCT05138263","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Active Not Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:17.508821+00:00","last_seen_at":"2026-09-25T06:10:45.89+00:00","metadata":{"sex":"ALL","acronym":"KBASE2","age_range":"20 Years to 90 Years","comparator":null,"organization":"Seoul National University Hospital","interventions":[],"registry_source":"ClinicalTrials.gov","outcome_measures":["Amount of brain amyloid deposition — baseline","Amount of brain tau deposition — baseline","Change of brain amyloid deposition — 2 years","Change of brain tau deposition — 2 years","Change of CERAD total score — 2 years","Change of cortical thickness — 2 years"],"design_description":null,"source_has_results":false},"controlled_terms":["Alzheimer Disease","Mild Cognitive Impairment"],"relevance_confidence":80,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: brain aging.","quality_checked_at":"2026-09-25T06:10:48.460085+00:00","duplicate_cluster_key":"id:nct05138263","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2022-01-01 to 2027-09-01","comparator":null,"confidence":"structured-source","population":"ALL · 20 Years to 90 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:45.897Z","intervention":[],"participants":640,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Amount of brain amyloid deposition — baseline","Amount of brain tau deposition — baseline","Change of brain amyloid deposition — 2 years","Change of brain tau deposition — 2 years","Change of CERAD total score — 2 years","Change of cortical thickness — 2 years"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"cognitive-aging","is_published":true,"match_reasons":["Title contains controlled term: brain aging.","Title supplies longevity context: aging.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Cognitive ageing","slug":"cognitive-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/22253","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}