{"type":"trials","record":{"id":22262,"source_id":"clinicaltrials-gov","external_id":"NCT03278119","title":"Sleep Aging and Risk for Alzheimer's 2.0","brief_summary":"Age-related sleep changes and common sleep disorders like obstructive sleep apnea (OSA) may increase amyloid burden and represent risk factors for cognitive decline in the elderly. We will directly interrogate the brain using a 2-night nocturnal polysomnography (NPSG) and amyloid deposition using C-PiB PET/MR both at baseline and at the 24-month follow-up. This study has the potential to identify the mechanisms by which age-related sleep changes contribute to AD neurodegeneration in cognitively normal elderly, the group that could profit the most from sleep preventive strategies.","overall_status":"Active Not Recruiting","phases":[],"study_type":"OBSERVATIONAL","sponsor":"NYU Langone Health","enrollment":158,"countries":["United States"],"start_date":"2018-05-01","completion_date":"2026-12-25","last_update_date":"2026-03-30","source_url":"https://clinicaltrials.gov/study/NCT03278119","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Active Not Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:17.508821+00:00","last_seen_at":"2026-09-25T06:10:45.89+00:00","metadata":{"sex":"ALL","acronym":"SARA","age_range":"55 Years to 75 Years","comparator":null,"organization":"NYU Langone Health","interventions":["PET Scan and nocturnal polysomnography"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Establishing how mild-to-moderate OSA increases AD risk will inform novel preventive therapies for AD. — 2.5 years","Establishing that SWS quality is associated with longitudinal amyloid deposition will identify a key mechanism by which…"],"design_description":null,"source_has_results":false},"controlled_terms":["Alzheimer Disease","Sleep Apnea","PET Scan and nocturnal polysomnography"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: sleep.","quality_checked_at":"2026-09-25T06:10:48.460085+00:00","duplicate_cluster_key":"id:nct03278119","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2018-05-01 to 2026-12-25","comparator":null,"confidence":"structured-source","population":"ALL · 55 Years to 75 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:45.899Z","intervention":["PET Scan and nocturnal polysomnography"],"participants":158,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Establishing how mild-to-moderate OSA increases AD risk will inform novel preventive therapies for AD. — 2.5 years","Establishing that SWS quality is associated with longitudinal amyloid deposition will identify a key mechanism by which…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"sleep","is_published":true,"match_reasons":["Title contains controlled term: sleep.","Abstract contains controlled term: sleep.","Source terminology contains: sleep.","Title supplies longevity context: aging.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Sleep","slug":"sleep"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/22262","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}