{"type":"trials","record":{"id":22264,"source_id":"clinicaltrials-gov","external_id":"NCT07485387","title":"Global Collaborative Research on Establishing a Korean Cognitive Aging Cohort","brief_summary":"The goal of this observational study is to learn how daily emotional stress affects cognitive function and inflammation in community-dwelling older adults aged 60 and older in Seoul, Republic of Korea. The main questions it aims to answer are: Does daily psychological stress measured in real-time affect short-term and long-term cognitive function in older adults? Do pro-inflammatory cytokines (such as CRP, IL-6, IL-10, and TNF-α) mediate the relationship between emotional stress and cognitive decline? How do social support and social isolation influence cognitive function and inflammatory biomarkers over time? Participants will: Complete baseline surveys assessing depression, cognitive function, and personal characteristics Use a smartphone app to answer brief surveys about their emotions, cognitive performance, and social interactions 1-6 times daily for two weeks Wear a Galaxy Watch to track sleep quality, heart rate, and physical activity Provide blood samples for inflammatory biomarker analysis Return for follow-up assessments at 6 months and 1 year This study is part of an international collaboration to establish a Korean cohort comparable to the U.S. Einstein Aging Study, with the aim of developing culturally tailored dementia prevention strategies.","overall_status":"Recruiting","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Korea University","enrollment":180,"countries":["South Korea"],"start_date":"2025-04-01","completion_date":"2037-12-31","last_update_date":"2026-03-20","source_url":"https://clinicaltrials.gov/study/NCT07485387","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:17.508821+00:00","last_seen_at":"2026-09-25T06:10:45.89+00:00","metadata":{"sex":"ALL","acronym":"KoCoA cohort","age_range":"60 Years","comparator":null,"organization":"Korea University","interventions":[],"registry_source":"ClinicalTrials.gov","outcome_measures":["Incident MCI and Dementia Diagnosis — baseline, 6-month, 1-year, 5-year and 10-year follow-up","SNSB-2 Composite Score — Baseline and 12 months","Wechsler Memory Scale Score — Baseline, 6 months, and 12 months","Block Design Subtest Score — Baseline, 6 months, and 12 months","EMA Daily Cognitive Task Performance — Daily during 2-week EMA period at baseline, 6 months, and 12 months","Plasma Phosphorylated Tau (p-tau) Level — Baseline, 6 months, and 12 months","Pro-Inflammatory Cytokine Composite Score — Baseline, 6 months, and 12 months","Plasma Amyloid Beta (Aβ) Level — Baseline, 6 months, and 12 months","ApoE Genotype — Baseline","EMA Daily Negative Affect — Daily during 2-week EMA period at baseline, 6 months, and 12 months","EMA Daily Positive Affect — Daily during 2-week EMA period at baseline, 6 months, and 12 months","Depressive Symptoms — Baseline, 6 months, and 12 months","EMA Daily Social Interaction Frequency — Daily during 2-week EMA period at baseline, 6 months, and 12 months","Daily Sleep Quality — Continuous during 2-week EMA period at baseline, 6 months, and 12 months","Daily Heart Rate Variability (HRV) — Continuous during 2-week EMA period at baseline, 6 months, and 12 months","Daily Physical Activity Level — Continuous during 2-week EMA period at baseline, 6 months, and 12 months","Serum C-Reactive Protein (CRP) Level — Baseline, 6 months, and 12 months"],"design_description":null,"source_has_results":false},"controlled_terms":["Mild Cognitive Impairment (MCI)","Dementia Alzheimer Type","Chronic Pain","Depression - Major Depressive Disorder"],"relevance_confidence":80,"source_quality_score":100,"freshness_score":85,"publication_state":"published","match_explanation":"Title contains controlled term: cognitive aging.","quality_checked_at":"2026-09-25T06:10:48.460085+00:00","duplicate_cluster_key":"id:nct07485387","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-04-01 to 2037-12-31","comparator":null,"confidence":"structured-source","population":"ALL · 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:45.899Z","intervention":[],"participants":180,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Incident MCI and Dementia Diagnosis — baseline, 6-month, 1-year, 5-year and 10-year follow-up","SNSB-2 Composite Score — Baseline and 12 months","Wechsler Memory Scale Score — Baseline, 6 months, and 12 months","Block Design Subtest Score — Baseline, 6 months, and 12 months","EMA Daily Cognitive Task Performance — Daily during 2-week EMA period at baseline, 6 months, and 12 months","Plasma Phosphorylated Tau (p-tau) Level — Baseline, 6 months, and 12 months","Pro-Inflammatory Cytokine Composite Score — Baseline, 6 months, and 12 months","Plasma Amyloid Beta (Aβ) Level — Baseline, 6 months, and 12 months","ApoE Genotype — Baseline","EMA Daily Negative Affect — Daily during 2-week EMA period at baseline, 6 months, and 12 months","EMA Daily Positive Affect — Daily during 2-week EMA period at baseline, 6 months, and 12 months","Depressive Symptoms — Baseline, 6 months, and 12 months","EMA Daily Social Interaction Frequency — Daily during 2-week EMA period at baseline, 6 months, and 12 months","Daily Sleep Quality — Continuous during 2-week EMA period at baseline, 6 months, and 12 months","Daily Heart Rate Variability (HRV) — Continuous during 2-week EMA period at baseline, 6 months, and 12 months","Daily Physical Activity Level — Continuous during 2-week EMA period at baseline, 6 months, and 12 months","Serum C-Reactive Protein (CRP) Level — Baseline, 6 months, and 12 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"cognitive-aging","is_published":true,"match_reasons":["Title contains controlled term: cognitive aging.","Title supplies longevity context: aging.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Cognitive ageing","slug":"cognitive-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/22264","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}