{"type":"trials","record":{"id":22266,"source_id":"clinicaltrials-gov","external_id":"NCT07466290","title":"L-serine and Strength Training in the Elderly","brief_summary":"This study investigates whether taking the amino acid L-serine, either alone or in combination with targeted strength training, can have a positive effect on mental performance, brain function, and physical fitness in older people. Healthy, independent women and men aged 65 to 85 are eligible to participate. Participants will be randomly assigned to one of three groups: placebo, L-serine, or L-serine combined with strength training. Cognitive tests, physical performance tests, and blood and brain tests will be conducted over a period of 48 weeks. The aim is to gain a better understanding of how nutrition and exercise can contribute to healthy aging.","overall_status":"Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University of Vienna","enrollment":126,"countries":["Austria"],"start_date":"2026-03-01","completion_date":"2028-12-01","last_update_date":"2026-03-12","source_url":"https://clinicaltrials.gov/study/NCT07466290","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:17.508821+00:00","last_seen_at":"2026-09-25T06:15:54.38+00:00","metadata":{"sex":"ALL","acronym":"AAAging","age_range":"65 Years to 85 Years","comparator":"L-serine supplementation; Control","organization":"University of Vienna","interventions":["Strength training","L-serine supplementation","Control (cornstarch)"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in cognitive performance measured by the Repeatable Battery for the Assessment of Neuropsychological Status (RBA…","Change in cognitive domain performance measured by index scores of RBANS — Baseline, 18 weeks and 48 weeks of intervent…","Change in hippocampal volume measured by magnetic resonance imaging (mm³) — Baseline and 48 weeks of intervention","Change in hippocampal functional connectivity measured by functional magnetic resonance imaging — Baseline and 48 weeks…","Change in oscillatory brain activity measured using electroencephalography — Baseline, 18 weeks and 48 weeks of interve…","Change in hippocampal neurometabolite concentrations measured using single voxel magnetic resonance spectroscopy — Base…","Change in lower limb muscle strength (isokinetic torque, dominant leg) — Baseline, 18 weeks and 48 weeks of intervention","Rate of torque development (Nm/s) will be measured at a joint angle of 60 degrees flexion (knee) and 40 degrees flexion…","Change in maximum and total work (J) of knee and hip flexion and extension — Baseline, 18 weeks and 48 of intervention","Position of peak torque and maximum range of motion (deg.) — Baseline, 18 weeks and 48 weeks of intervention","Change in time to peak torque and time from peak to relaxation (sec.) during knee and hip extension and flexion — Basel…","Mean power (W) in knee and hip extension and flexion — Baseline, 18 weeks, and 48 weeks of intervention","Change in isometric handgrip strength — Baseline, 18 weeks, and 48 weeks of intervention","Change in upper extremity functional performance measured by the 30-Second Arm Curl Test — Baseline, 18 weeks, and 48 w…","Change in upper-body flexibility (Back Scratch Test) — Baseline, 18 weeks, and 48 weeks of intervention","Change in Lower body flexibility (Chair Sit and Reach Test) — Baseline, 18 weeks, and 48 weeks of intervention","Change in lower extremity functional muscular performance measured by the 30-Second Chair Stand Test — Baseline, 18 wee…","Mobility and dynamic balance (Stand Up and Go Test) — Baseline, 18 weeks, and 48 weeks of intervention","Change in body composition measured by bioelectrical impedance analysis — Baseline, 18 weeks, and 48 weeks of intervent…","Change in waist, abdominal, hip circumference (cm) — Baseline, 18 weeks, and 48 weeks of intervention"],"design_description":"RANDOMIZED · PARALLEL · BASIC SCIENCE · QUADRUPLE","source_has_results":false},"controlled_terms":["Brain Health","Longevity","Cognitive Performance","Strength Training Effects","Healthy Ageing","Ageing","Cognition","Memory","Muscle Strength","Strength training","L-serine supplementation","Control (cornstarch)"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":85,"publication_state":"published","match_explanation":"Title contains controlled term: strength training.","quality_checked_at":"2026-09-25T06:16:07.48358+00:00","duplicate_cluster_key":"id:nct07466290","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2026-03-01 to 2028-12-01","comparator":"L-serine supplementation; Control","confidence":"structured-source","population":"ALL · 65 Years to 85 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:54.415Z","intervention":["Strength training","L-serine supplementation","Control (cornstarch)"],"participants":126,"study_design":"RANDOMIZED · PARALLEL · BASIC SCIENCE · QUADRUPLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in cognitive performance measured by the Repeatable Battery for the Assessment of Neuropsychological Status (RBA…","Change in cognitive domain performance measured by index scores of RBANS — Baseline, 18 weeks and 48 weeks of intervent…","Change in hippocampal volume measured by magnetic resonance imaging (mm³) — Baseline and 48 weeks of intervention","Change in hippocampal functional connectivity measured by functional magnetic resonance imaging — Baseline and 48 weeks…","Change in oscillatory brain activity measured using electroencephalography — Baseline, 18 weeks and 48 weeks of interve…","Change in hippocampal neurometabolite concentrations measured using single voxel magnetic resonance spectroscopy — Base…","Change in lower limb muscle strength (isokinetic torque, dominant leg) — Baseline, 18 weeks and 48 weeks of intervention","Rate of torque development (Nm/s) will be measured at a joint angle of 60 degrees flexion (knee) and 40 degrees flexion…","Change in maximum and total work (J) of knee and hip flexion and extension — Baseline, 18 weeks and 48 of intervention","Position of peak torque and maximum range of motion (deg.) — Baseline, 18 weeks and 48 weeks of intervention","Change in time to peak torque and time from peak to relaxation (sec.) during knee and hip extension and flexion — Basel…","Mean power (W) in knee and hip extension and flexion — Baseline, 18 weeks, and 48 weeks of intervention","Change in isometric handgrip strength — Baseline, 18 weeks, and 48 weeks of intervention","Change in upper extremity functional performance measured by the 30-Second Arm Curl Test — Baseline, 18 weeks, and 48 w…","Change in upper-body flexibility (Back Scratch Test) — Baseline, 18 weeks, and 48 weeks of intervention","Change in Lower body flexibility (Chair Sit and Reach Test) — Baseline, 18 weeks, and 48 weeks of intervention","Change in lower extremity functional muscular performance measured by the 30-Second Chair Stand Test — Baseline, 18 wee…","Mobility and dynamic balance (Stand Up and Go Test) — Baseline, 18 weeks, and 48 weeks of intervention","Change in body composition measured by bioelectrical impedance analysis — Baseline, 18 weeks, and 48 weeks of intervent…","Change in waist, abdominal, hip circumference (cm) — Baseline, 18 weeks, and 48 weeks of intervention"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"resistance-training","is_published":true,"match_reasons":["Title contains controlled term: strength training.","Abstract contains controlled term: strength training.","Source terminology contains: strength training.","Title supplies longevity context: elderly.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Resistance training","slug":"resistance-training"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/22266","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}