{"type":"trials","record":{"id":22308,"source_id":"clinicaltrials-gov","external_id":"NCT06555978","title":"Ageing BIOmarker Study in Singaporeans","brief_summary":"The Ageing BIOmarker Study in Singaporeans (ABIOS) aims to understand the biological aging processes and how they affect health among people in Singapore. As people grow older, their risk of developing chronic diseases increases. This study aims to better understand the biological changes that come with age, particularly in three major ethnic groups: Chinese, Malay, and Indian adults over 21 years old. By examining a range of health indicators such as DNA methylation, inflammation, metabolism, cardiovascular health, physical function, and physical activity (i.e., molecular, physiological, and digital biomarkers of ageing), the study seeks to identify how ethnicity, lifestyle, and socioeconomic factors influence ageing. This unique study focuses on an all-Asian population, aiming to enhance our understanding of healthy aging across different ethnic groups.","overall_status":"Active Not Recruiting","phases":[],"study_type":"OBSERVATIONAL","sponsor":"National University of Singapore","enrollment":378,"countries":["Singapore"],"start_date":"2021-03-12","completion_date":"2028-12-31","last_update_date":"2026-06-01","source_url":"https://clinicaltrials.gov/study/NCT06555978","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Active Not Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:17.955692+00:00","last_seen_at":"2026-09-25T06:15:13.984+00:00","metadata":{"sex":"ALL","acronym":"ABIOS","age_range":"21 Years","comparator":null,"organization":"National University of Singapore","interventions":[],"registry_source":"ClinicalTrials.gov","outcome_measures":["blood DNA methylation — Baseline","Carotid-femoral Pulse Wave Velocity — Baseline","Handgrip strength — Baseline","8-repetition maximal strength — Baseline","Skin advanced glycation endproducts — Baseline","Objective physical activity — Baseline","Facial age — Baseline","Complete red blood cell (RBC) count — Baseline","Total white blood cell (WBC) count — Baseline","Total cholesterol — Baseline","HDL cholesterol — Baseline","LDL cholesterol — Baseline","Triglycerides — Baseline","Fasting blood glucose — Baseline","Total protein — Baseline","Total bilirubin — Baseline","Alkaline phosphatase (ALP) — Baseline","Insulin — Baseline","HbA1c — Baseline"],"design_description":null,"source_has_results":false},"controlled_terms":["Healthy Aging","Biological Aging","Lifestyle Factors"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: ageing biomarker.","quality_checked_at":"2026-09-25T06:15:15.562724+00:00","duplicate_cluster_key":"id:nct06555978","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2021-03-12 to 2028-12-31","comparator":null,"confidence":"structured-source","population":"ALL · 21 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:13.992Z","intervention":[],"participants":378,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["blood DNA methylation — Baseline","Carotid-femoral Pulse Wave Velocity — Baseline","Handgrip strength — Baseline","8-repetition maximal strength — Baseline","Skin advanced glycation endproducts — Baseline","Objective physical activity — Baseline","Facial age — Baseline","Complete red blood cell (RBC) count — Baseline","Total white blood cell (WBC) count — Baseline","Total cholesterol — Baseline","HDL cholesterol — Baseline","LDL cholesterol — Baseline","Triglycerides — Baseline","Fasting blood glucose — Baseline","Total protein — Baseline","Total bilirubin — Baseline","Alkaline phosphatase (ALP) — Baseline","Insulin — Baseline","HbA1c — Baseline"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"biological-age-biomarkers","is_published":true,"match_reasons":["Title contains controlled term: ageing biomarker.","Abstract contains controlled term: ageing biomarker.","Title supplies longevity context: ageing.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Biological age biomarkers","slug":"biological-age-biomarkers"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/22308","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}