{"type":"trials","record":{"id":22318,"source_id":"clinicaltrials-gov","external_id":"NCT07448818","title":"Dynamic and Isometric Strength Training in Older Adults With Hypertension","brief_summary":"This feasibility study aims to evaluate the effects of dynamic strength training and isometric strength training on cardiovascular health indicators, mental health, and neuromuscular fitness in older adults with hypertension. Participants will be randomly assigned to one of the two training modalities and will complete supervised exercise sessions throughout the intervention period. The study will provide preliminary evidence regarding the safety, acceptability, and potential impact of each training modality on health outcomes in this population.","overall_status":"Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Raphael Mendes Ritti Dias","enrollment":60,"countries":["Brazil"],"start_date":"2026-03-01","completion_date":"2027-12-31","last_update_date":"2026-05-01","source_url":"https://clinicaltrials.gov/study/NCT07448818","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:17.955692+00:00","last_seen_at":"2026-09-25T06:10:49.917+00:00","metadata":{"sex":"ALL","acronym":"Dynamic and Is","age_range":"60 Years","comparator":"Dynamic Strength Training","organization":"University of Nove de Julho","interventions":["Dynamic Strength Training","Isometric Strength Training","No supervised intervention Control"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Recruitment rate — Baseline and 6 weeks","Adherence to training sessions — During 6 weeks","Retention rate — During 6 weeks","Fidelity to exercise protocol — Duiring 6 weeks","Acceptability of the intervention — During 6 weeks","Occurrence of adverse events — During 6 weeks","Change from baseline in Clinical resting blood pressure at 6 weeks — Baseline and 6 weeks","Change from baseline in Home blood pressure monitoring at 6 weeks — Baseline and 6 weeks","Change from baseline in Flow-mediated dilation at 6 weeks — Baseline and 6 weeks","Change from baseline in Standard deviation of normal R-R intervals at 6 weeks — Baseline and 6 weeks","Change from baseline in Arterial stiffness at 6 weeks — Baseline and 6 weeks","Change from baseline in Depressive symptoms at 6 weeks — Baseline and 6 weeks","Change from baseline in Anxiety symptoms at 6 weeks — Baseline and 6 weeks","Change from baseline in Six-Minute Walk Test distance at 6 weeks — Baseline and 6 weeks","Change from baseline in Root mean square of successive differences between R-R intervals at 6 weeks — Baseline to 6 wee…","Change from baseline in Proportion of successive R-R intervals differing by more than 50 milliseconds at 6 weeks — Base…","Change from baseline in Low-frequency spectral power at 6 weeks — Baseline to 6 weeks.","Change from baseline in high-frequency power at 6 weeks — Baseline to 6 weeks.","Change from baseline in Low-frequency to high-frequency ratio at 6 weeks — Baseline to 6 weeks.","Change from baseline in Timed Up and Go Time at 6 weeks — Baseline and 6 weeks."],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · NONE","source_has_results":false},"controlled_terms":["Hypertension","Elderly (People Aged 65 or More)","Dynamic Strength Training","Isometric Strength Training","No supervised intervention Control"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: strength training.","quality_checked_at":"2026-09-25T06:10:57.79658+00:00","duplicate_cluster_key":"id:nct07448818","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2026-03-01 to 2027-12-31","comparator":"Dynamic Strength Training","confidence":"structured-source","population":"ALL · 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:49.926Z","intervention":["Dynamic Strength Training","Isometric Strength Training","No supervised intervention Control"],"participants":60,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Recruitment rate — Baseline and 6 weeks","Adherence to training sessions — During 6 weeks","Retention rate — During 6 weeks","Fidelity to exercise protocol — Duiring 6 weeks","Acceptability of the intervention — During 6 weeks","Occurrence of adverse events — During 6 weeks","Change from baseline in Clinical resting blood pressure at 6 weeks — Baseline and 6 weeks","Change from baseline in Home blood pressure monitoring at 6 weeks — Baseline and 6 weeks","Change from baseline in Flow-mediated dilation at 6 weeks — Baseline and 6 weeks","Change from baseline in Standard deviation of normal R-R intervals at 6 weeks — Baseline and 6 weeks","Change from baseline in Arterial stiffness at 6 weeks — Baseline and 6 weeks","Change from baseline in Depressive symptoms at 6 weeks — Baseline and 6 weeks","Change from baseline in Anxiety symptoms at 6 weeks — Baseline and 6 weeks","Change from baseline in Six-Minute Walk Test distance at 6 weeks — Baseline and 6 weeks","Change from baseline in Root mean square of successive differences between R-R intervals at 6 weeks — Baseline to 6 wee…","Change from baseline in Proportion of successive R-R intervals differing by more than 50 milliseconds at 6 weeks — Base…","Change from baseline in Low-frequency spectral power at 6 weeks — Baseline to 6 weeks.","Change from baseline in high-frequency power at 6 weeks — Baseline to 6 weeks.","Change from baseline in Low-frequency to high-frequency ratio at 6 weeks — Baseline to 6 weeks.","Change from baseline in Timed Up and Go Time at 6 weeks — Baseline and 6 weeks."],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"resistance-training","is_published":true,"match_reasons":["Title contains controlled term: strength training.","Abstract contains controlled term: strength training.","Source terminology contains: strength training.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Resistance training","slug":"resistance-training"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/22318","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}