{"type":"trials","record":{"id":22319,"source_id":"clinicaltrials-gov","external_id":"NCT05296395","title":"Vascular Aging and Lp299v Study in Healthy Adults","brief_summary":"Emerging data suggest the gut microbiota regulates multiple mechanisms related to vascular aging, but no intervention targeting the gut microbiota has been tested in older adults without cardiovascular risk factors or cardiovascular disease. Early human data suggest an increase in potentially pathological gut metabolites such as trimethylamine-N-oxide (TMAO) are associated with older age, increased vascular stiffness, increased oxidative stress, and reduced nitric oxide (NO) bioavailability as evidenced by impaired endothelium-dependent vasodilation. Based on this data, the investigators hypothesize that supplementation with Lp299v will reverse human vascular aging in healthy older adults free of known traditional cardiovascular risk factors.","overall_status":"Active Not Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Medical College of Wisconsin","enrollment":20,"countries":["United States"],"start_date":"2023-02-01","completion_date":"2027-09-22","last_update_date":"2026-05-01","source_url":"https://clinicaltrials.gov/study/NCT05296395","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Active Not Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:17.955692+00:00","last_seen_at":"2026-09-25T06:15:54.38+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"50 Years to 99 Years","comparator":"Heat-killed placebo control","organization":"Medical College of Wisconsin","interventions":["Lactobacillus Plantarum 299v in fermented oat drink","Heat-Killed Placebo control fermented drink"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Brachial Artery Flow Mediated Dilation (FMD% — 6 weeks","Nitroglycerin-Mediated Vasodilation of the brachial artery (NMD) — 6 weeks","Hyperemic Flow Velocity — 6 weeks","Carotid-Femoral Pulse Wave Velocity (cfPWV) — 6 weeks","Stool microbiota alpha diversity — 6 weeks","Stool microbiota beta diversity — 6 weeks","Brachial Artery Resting Diameter — 6 weeks"],"design_description":"RANDOMIZED · CROSSOVER · BASIC SCIENCE · QUADRUPLE","source_has_results":false},"controlled_terms":["Vascular Aging","Lactobacillus Plantarum 299v in fermented oat drink","Heat-Killed Placebo control fermented drink"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: vascular aging.","quality_checked_at":"2026-09-25T06:16:07.48358+00:00","duplicate_cluster_key":"id:nct05296395","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2023-02-01 to 2027-09-22","comparator":"Heat-killed placebo control","confidence":"structured-source","population":"ALL · 50 Years to 99 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:54.410Z","intervention":["Lactobacillus Plantarum 299v in fermented oat drink","Heat-Killed Placebo control fermented drink"],"participants":20,"study_design":"RANDOMIZED · CROSSOVER · BASIC SCIENCE · QUADRUPLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Brachial Artery Flow Mediated Dilation (FMD% — 6 weeks","Nitroglycerin-Mediated Vasodilation of the brachial artery (NMD) — 6 weeks","Hyperemic Flow Velocity — 6 weeks","Carotid-Femoral Pulse Wave Velocity (cfPWV) — 6 weeks","Stool microbiota alpha diversity — 6 weeks","Stool microbiota beta diversity — 6 weeks","Brachial Artery Resting Diameter — 6 weeks"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"cardiovascular-aging","is_published":true,"match_reasons":["Title contains controlled term: vascular aging.","Abstract contains controlled term: vascular aging.","Source terminology contains: vascular aging.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Cardiovascular ageing","slug":"cardiovascular-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/22319","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}