{"type":"trials","record":{"id":22349,"source_id":"clinicaltrials-gov","external_id":"NCT07476911","title":"The Impact of Aerobic Exercise Program on Immunosenescence Institutionalized Older Adults","brief_summary":"Background: Immunosenescence is an age-related decline in immune function, associated with chronic low-grade inflammation, increased morbidity, and functional impairment in older adults. Aerobic exercise has been proposed as an effective non-pharmacological strategy to counteract these alterations; however, evidence from randomized-controlled trials (RCTs), particularly in institutionalized elderly populations, remains scarce and methodologically limited. Objective: This study protocol aims to investigate the effects of short- and medium-term aerobic exercise programs on immunosenescence in institutionalized older adults, as well as to analyze the impact of a detraining period and a subsequent reintervention. Methods: A stratified RCT will be conducted with institutionalized adults aged ≥60 years, randomly allocated to an aerobic exercise group or a control group. The intervention consists of a supervised 12-week moderate-intensity aerobic exercise program (three sessions/week), followed by a 4-week detraining period and a 4-week reintervention. Assessments will be performed at five time points. Primary outcomes include immunological and analytical parameters assessed by spectral flow cytometry and multiplex cytokine analysis. Secondary outcomes include anthropometry, functional capacity, hemodynamic parameters, heart rate variability, and psychological indicators. Expected Results: Aerobic exercise is expected to induce favorable immunological adaptations, partially reverse immunosenescence, and improve functional and psychosocial outcomes.","overall_status":"Not Yet Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Instituto Politécnico de Castelo Branco","enrollment":40,"countries":[],"start_date":"2026-03-02","completion_date":"2026-10-30","last_update_date":"2026-03-17","source_url":"https://clinicaltrials.gov/study/NCT07476911","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Not Yet Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:18.351868+00:00","last_seen_at":"2026-09-25T06:15:06.064+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"60 Years","comparator":"Control Group","organization":"Instituto Politécnico de Castelo Branco","interventions":["Aerobic exercise program"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Sodium — Baseline (T0); After 6 weeks of intervention (T6); After 12 weeks of intervention (T12); After 4 week detraini…","Potassium — Baseline (T0); After 6 weeks of intervention (T6); After 12 weeks of intervention (T12); After 4 week detra…","Chloride — Baseline (T0); After 6 weeks of intervention (T6); After 12 weeks of intervention (T12); After 4 week detrai…","Calcium — Baseline (T0); After 6 weeks of intervention (T6); After 12 weeks of intervention (T12); After 4 week detrain…","Phosphorus — Baseline (T0); After 6 weeks of intervention (T6); After 12 weeks of intervention (T12); After 4 week detr…","Magnesium — Baseline (T0); After 6 weeks of intervention (T6); After 12 weeks of intervention (T12); After 4 week detra…","Aspartate aminotransferase (AST) — Baseline (T0); After 6 weeks of intervention (T6); After 12 weeks of intervention (T…","Alanine aminotransferase (ALT) — Baseline (T0); After 6 weeks of intervention (T6); After 12 weeks of intervention (T12…","Gamma-glutamyl transferase (GGT) — Baseline (T0); After 6 weeks of intervention (T6); After 12 weeks of intervention (T…","Total bilirubin — Baseline (T0); After 6 weeks of intervention (T6); After 12 weeks of intervention (T12); After 4 week…","Direct bilirubin — Baseline (T0); After 6 weeks of intervention (T6); After 12 weeks of intervention (T12); After 4 wee…","Alkaline phosphatase — Baseline (T0); After 6 weeks of intervention (T6); After 12 weeks of intervention (T12); After 4…","Lactate dehydrogenase (LDH) — Baseline (T0); After 6 weeks of intervention (T6); After 12 weeks of intervention (T12);…","Total cholesterol — Baseline (T0); After 6 weeks of intervention (T6); After 12 weeks of intervention (T12); After 4 we…","HDL cholesterol — Baseline (T0); After 6 weeks of intervention (T6); After 12 weeks of intervention (T12); After 4 week…","LDL cholesterol — Baseline (T0); After 6 weeks of intervention (T6); After 12 weeks of intervention (T12); After 4 week…","Triglycerides — Baseline (T0); After 6 weeks of intervention (T6); After 12 weeks of intervention (T12); After 4 week d…","Amylase — Baseline (T0); After 6 weeks of intervention (T6); After 12 weeks of intervention (T12); After 4 week detrain…","Urea — Baseline (T0); After 6 weeks of intervention (T6); After 12 weeks of intervention (T12); After 4 week detraining…","Creatinine — Baseline (T0); After 6 weeks of intervention (T6); After 12 weeks of intervention (T12); After 4 week detr…"],"design_description":"RANDOMIZED · PARALLEL · PREVENTION · DOUBLE","source_has_results":false},"controlled_terms":["Immunosenescence","Aging","Aerobic exercise program"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":85,"publication_state":"published","match_explanation":"Title contains controlled term: exercise.","quality_checked_at":"2026-09-25T06:15:09.632521+00:00","duplicate_cluster_key":"id:nct07476911","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2026-03-02 to 2026-10-30","comparator":"Control Group","confidence":"structured-source","population":"ALL · 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:06.079Z","intervention":["Aerobic exercise program"],"participants":40,"study_design":"RANDOMIZED · PARALLEL · PREVENTION · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Sodium — Baseline (T0); After 6 weeks of intervention (T6); After 12 weeks of intervention (T12); After 4 week detraini…","Potassium — Baseline (T0); After 6 weeks of intervention (T6); After 12 weeks of intervention (T12); After 4 week detra…","Chloride — Baseline (T0); After 6 weeks of intervention (T6); After 12 weeks of intervention (T12); After 4 week detrai…","Calcium — Baseline (T0); After 6 weeks of intervention (T6); After 12 weeks of intervention (T12); After 4 week detrain…","Phosphorus — Baseline (T0); After 6 weeks of intervention (T6); After 12 weeks of intervention (T12); After 4 week detr…","Magnesium — Baseline (T0); After 6 weeks of intervention (T6); After 12 weeks of intervention (T12); After 4 week detra…","Aspartate aminotransferase (AST) — Baseline (T0); After 6 weeks of intervention (T6); After 12 weeks of intervention (T…","Alanine aminotransferase (ALT) — Baseline (T0); After 6 weeks of intervention (T6); After 12 weeks of intervention (T12…","Gamma-glutamyl transferase (GGT) — Baseline (T0); After 6 weeks of intervention (T6); After 12 weeks of intervention (T…","Total bilirubin — Baseline (T0); After 6 weeks of intervention (T6); After 12 weeks of intervention (T12); After 4 week…","Direct bilirubin — Baseline (T0); After 6 weeks of intervention (T6); After 12 weeks of intervention (T12); After 4 wee…","Alkaline phosphatase — Baseline (T0); After 6 weeks of intervention (T6); After 12 weeks of intervention (T12); After 4…","Lactate dehydrogenase (LDH) — Baseline (T0); After 6 weeks of intervention (T6); After 12 weeks of intervention (T12);…","Total cholesterol — Baseline (T0); After 6 weeks of intervention (T6); After 12 weeks of intervention (T12); After 4 we…","HDL cholesterol — Baseline (T0); After 6 weeks of intervention (T6); After 12 weeks of intervention (T12); After 4 week…","LDL cholesterol — Baseline (T0); After 6 weeks of intervention (T6); After 12 weeks of intervention (T12); After 4 week…","Triglycerides — Baseline (T0); After 6 weeks of intervention (T6); After 12 weeks of intervention (T12); After 4 week d…","Amylase — Baseline (T0); After 6 weeks of intervention (T6); After 12 weeks of intervention (T12); After 4 week detrain…","Urea — Baseline (T0); After 6 weeks of intervention (T6); After 12 weeks of intervention (T12); After 4 week detraining…","Creatinine — Baseline (T0); After 6 weeks of intervention (T6); After 12 weeks of intervention (T12); After 4 week detr…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"exercise","is_published":true,"match_reasons":["Title contains controlled term: exercise.","Abstract contains controlled term: exercise.","Source terminology contains: exercise.","Title supplies longevity context: senescence, older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Exercise","slug":"exercise"}},{"topic_slug":"immune-aging","is_published":true,"match_reasons":["Title contains controlled term: immunosenescence.","Abstract contains controlled term: immunosenescence.","Source terminology contains: immunosenescence.","Title supplies longevity context: senescence, older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Immune ageing","slug":"immune-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/22349","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}