{"type":"trials","record":{"id":22353,"source_id":"clinicaltrials-gov","external_id":"NCT06809868","title":"Role of Transposable Elements in Septic Immune Aging","brief_summary":"The goal of this observational study is to learn about how transposable element levels affect the patient outcomes in sepsis. The main questions it aims to answer is: 1. Do transposable elements prematurely age the immune systems of patients with sepsis? 2. Do transposable elements correlate with increased mortality in patients with sepsis in the ICU? 3. Do transposable elements correlate with increased amount of secondary infections in patients with sepsis in the ICU? Participants will have blood drawn from them but will not be subjected to additional interventions.","overall_status":"Recruiting","phases":[],"study_type":"OBSERVATIONAL","sponsor":"University of California, San Francisco","enrollment":116,"countries":["United States"],"start_date":"2025-02-14","completion_date":"2028-08-14","last_update_date":"2026-01-30","source_url":"https://clinicaltrials.gov/study/NCT06809868","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:18.351868+00:00","last_seen_at":"2026-09-25T06:15:06.064+00:00","metadata":{"sex":"ALL","acronym":"SITE","age_range":"18 Years","comparator":null,"organization":"University of California, San Francisco","interventions":["RNA and DNA Sequencing"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Immune Aging — 6 weeks","Mortality (30-day) — 30 days","Secondary Infection — 30 days"],"design_description":null,"source_has_results":false},"controlled_terms":["Sepsis","Sepsis and Septic Shock","Sepsis With Multiple Organ Dysfunction (MOD)","Sepsis With Acute Organ Dysfunction","Sepsis, Severe","Sepsis at Intensive Care Unit","Sepsis, Severe Sepsis and Septic Shock","Sepsis, Septic Shock","RNA and DNA Sequencing"],"relevance_confidence":80,"source_quality_score":100,"freshness_score":85,"publication_state":"published","match_explanation":"Title contains controlled term: immune aging.","quality_checked_at":"2026-09-25T06:15:09.632521+00:00","duplicate_cluster_key":"id:nct06809868","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-02-14 to 2028-08-14","comparator":null,"confidence":"structured-source","population":"ALL · 18 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:06.080Z","intervention":["RNA and DNA Sequencing"],"participants":116,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Immune Aging — 6 weeks","Mortality (30-day) — 30 days","Secondary Infection — 30 days"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"immune-aging","is_published":true,"match_reasons":["Title contains controlled term: immune aging.","Title supplies longevity context: aging.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Immune ageing","slug":"immune-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/22353","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}