{"type":"trials","record":{"id":22370,"source_id":"clinicaltrials-gov","external_id":"NCT06295354","title":"Early Variations in Immune Aging","brief_summary":"Background: Despite an increase in lifespan over the last decades, our healthspan lags behind. In our aging population, it is pressing that we prevent age-related morbidities and associated burden on the health care system. Instead of investigating aging in already aged populations, the currently proposed study aims to elucidate the process of immune aging in relation to biological aging, demographic and lifestyle factors in young and midlife adults, and to identify early biomarkers and pathways associated with fast versus slow immune aging and aging endotypes. Study design: A single-center, observational prospective cohort study in the Netherlands. Participants from priorly established cohorts will be invited to join the EVIA-study. We will obtain demographic and basic clinical data and biological samples (blood and stool) at baseline and after three years, with a short, yearly online questionnaire in between.","overall_status":"Terminated","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Radboud University Medical Center","enrollment":1000,"countries":["Netherlands"],"start_date":"2024-10-07","completion_date":"2025-03-18","last_update_date":"2025-05-01","source_url":"https://clinicaltrials.gov/study/NCT06295354","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Terminated. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:18.351868+00:00","last_seen_at":"2026-09-25T06:15:06.064+00:00","metadata":{"sex":"ALL","acronym":"EVIA-NL","age_range":"20 Years to 60 Years","comparator":null,"organization":"Radboud University Medical Center","interventions":["No intervention, we just study 'aging'"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Immunological function — At baseline and after 3 years","Immunological Aging Score — At baseline and after 3 years","Biological Aging Score — At baseline and after 3 years","Metagenomics — At baseline and after 3 years","Genetics and epigenetics — At baseline and after 3 years","Clinical events — Between baseline and the 3-year timepoint"],"design_description":null,"source_has_results":false},"controlled_terms":["Aging","Aging Well","Immuno Aging","No intervention, we just study 'aging'"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: immune aging.","quality_checked_at":"2026-09-25T06:15:09.632521+00:00","duplicate_cluster_key":"id:nct06295354","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2024-10-07 to 2025-03-18","comparator":null,"confidence":"structured-source","population":"ALL · 20 Years to 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:06.084Z","intervention":["No intervention, we just study 'aging'"],"participants":1000,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Immunological function — At baseline and after 3 years","Immunological Aging Score — At baseline and after 3 years","Biological Aging Score — At baseline and after 3 years","Metagenomics — At baseline and after 3 years","Genetics and epigenetics — At baseline and after 3 years","Clinical events — Between baseline and the 3-year timepoint"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"immune-aging","is_published":true,"match_reasons":["Title contains controlled term: immune aging.","Abstract contains controlled term: immune aging.","Title supplies longevity context: aging.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Immune ageing","slug":"immune-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/22370","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}