{"type":"trials","record":{"id":22373,"source_id":"clinicaltrials-gov","external_id":"NCT06887075","title":"Systemic Activation of Inflammasomes and Frailty in Older Candidates to Kidney Transplantation","brief_summary":"Kidney transplantation (KT) benefit-risk ratio assessment is a challenge in a growing population of older patients with end-stage kidney disease. A pre-KT frailty phenotype has been found predictive of post-KT complications, but biological mechanisms of frailty are poorly known is these patients. Frailty is associated with chronic low-grade inflammation in the older general population, possibly through the inflammasome pathway. Our main objective is to assess if systemic activation of inflammasomes is associated with frailty in older candidates to KT.","overall_status":"Not Yet Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University Hospital, Bordeaux","enrollment":60,"countries":["France"],"start_date":"2025-04-15","completion_date":"2027-02-15","last_update_date":"2025-03-20","source_url":"https://clinicaltrials.gov/study/NCT06887075","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Not Yet Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:18.351868+00:00","last_seen_at":"2026-09-25T06:15:06.064+00:00","metadata":{"sex":"ALL","acronym":"INTRA","age_range":"70 Years","comparator":"Frail Patients; non frail patients","organization":"University Hospital, Bordeaux","interventions":["Blood sample","Geriatric assessment standardized"],"registry_source":"ClinicalTrials.gov","outcome_measures":["IL1 — at recruitment (up to 30 days)","IL18 — at recruitment (up to 30 days)","inflammasomes genes — at recruitment (up to 30 days)","inflammasome platform — at recruitment (up to 30 days)","Weight — at enrollment (Day 0), at recruitment (up to 30 days)","Activity — at enrollment (Day 0), at recruitment (up to 30 days)","Gait — at enrollment (day 0), at recruitment (up to 30 days)","Handgrip strength — at enrollment (day 0), at recruitment (up to 30 days)","Comorbidity — at recruitment (up to 30 days)","decline — at recruitment (up to 30 days)","Physical performance — at recruitment (up to 30 days)","Cognitive functions — at recruitment (up to 30 days)","Depression — at recruitment (up to 30 days)","Nutrition — at recruitment (up to 30 days)","Snellen test — at recruitment (up to 30 days)","ADL — at recruitment (up to 30 days)","Immunophenotyping — at recruitment (up to 30 days)","CRP — at recruitment (up to 30 days)","IL-6 — at recruitment (up to 30 days)","MCP-1 — at recruitment (up to 30 days)"],"design_description":"NON RANDOMIZED · PARALLEL · DIAGNOSTIC · NONE","source_has_results":false},"controlled_terms":["Chronic Kidney Failure","Frailty","Aging","Inflammation","Blood sample","Geriatric assessment standardized"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: frailty.","quality_checked_at":"2026-09-25T06:15:09.632521+00:00","duplicate_cluster_key":"id:nct06887075","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-04-15 to 2027-02-15","comparator":"Frail Patients; non frail patients","confidence":"structured-source","population":"ALL · 70 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:06.084Z","intervention":["Blood sample","Geriatric assessment standardized"],"participants":60,"study_design":"NON RANDOMIZED · PARALLEL · DIAGNOSTIC · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["IL1 — at recruitment (up to 30 days)","IL18 — at recruitment (up to 30 days)","inflammasomes genes — at recruitment (up to 30 days)","inflammasome platform — at recruitment (up to 30 days)","Weight — at enrollment (Day 0), at recruitment (up to 30 days)","Activity — at enrollment (Day 0), at recruitment (up to 30 days)","Gait — at enrollment (day 0), at recruitment (up to 30 days)","Handgrip strength — at enrollment (day 0), at recruitment (up to 30 days)","Comorbidity — at recruitment (up to 30 days)","decline — at recruitment (up to 30 days)","Physical performance — at recruitment (up to 30 days)","Cognitive functions — at recruitment (up to 30 days)","Depression — at recruitment (up to 30 days)","Nutrition — at recruitment (up to 30 days)","Snellen test — at recruitment (up to 30 days)","ADL — at recruitment (up to 30 days)","Immunophenotyping — at recruitment (up to 30 days)","CRP — at recruitment (up to 30 days)","IL-6 — at recruitment (up to 30 days)","MCP-1 — at recruitment (up to 30 days)"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Abstract contains controlled term: frailty.","Source terminology contains: frailty.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/22373","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}