{"type":"trials","record":{"id":22405,"source_id":"clinicaltrials-gov","external_id":"NCT07214246","title":"Follicular Fluid microRNAs in Ovarian Aging and Reproduction","brief_summary":"The purpose of this study is to investigate the role of exosomal microRNAs (miRNAs) in follicular fluid (FF) as biomarkers of ovarian aging and predictors of in vitro fertilization (IVF) outcomes. The goal is to identify noninvasive molecular markers that correlate with oocyte quality and reproductive potential, particularly in women of advanced maternal age.","overall_status":"Recruiting","phases":[],"study_type":"OBSERVATIONAL","sponsor":"University of Central Florida","enrollment":100,"countries":["United States"],"start_date":"2025-09-22","completion_date":"2026-09-01","last_update_date":"2025-10-09","source_url":"https://clinicaltrials.gov/study/NCT07214246","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:18.765619+00:00","last_seen_at":"2026-09-25T06:15:10.83+00:00","metadata":{"sex":"FEMALE","acronym":null,"age_range":"18 Years","comparator":null,"organization":"University of Central Florida","interventions":["No Interventions"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Identify exosomal miRNAs using RNA sequencing — 1 year","Validate and assess miRNA for IVF — 1 year","Determine molecular pathways regulated by age — 1 year"],"design_description":null,"source_has_results":false},"controlled_terms":["Ovarian Aging","In Vitro Fertilisation (IVF) Treatment","InVitro Fertilization","In Vitro Fertilization Outcome","No Interventions"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":85,"publication_state":"published","match_explanation":"Title contains controlled term: ovarian aging.","quality_checked_at":"2026-09-25T06:15:11.94354+00:00","duplicate_cluster_key":"id:nct07214246","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-09-22 to 2026-09-01","comparator":null,"confidence":"structured-source","population":"FEMALE · 18 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:10.838Z","intervention":["No Interventions"],"participants":100,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Identify exosomal miRNAs using RNA sequencing — 1 year","Validate and assess miRNA for IVF — 1 year","Determine molecular pathways regulated by age — 1 year"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"ovarian-aging","is_published":true,"match_reasons":["Title contains controlled term: ovarian aging.","Abstract contains controlled term: ovarian aging.","Source terminology contains: ovarian aging.","Title supplies longevity context: aging.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Ovarian ageing","slug":"ovarian-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/22405","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}