{"type":"trials","record":{"id":22409,"source_id":"clinicaltrials-gov","external_id":"NCT06794060","title":"Therapeutic Effect of Vitamin C Supplementation in Patients With Ovarian Aging","brief_summary":"The goal of this clinical trial is to learn if Vitamin C works to improve ovarian reserve in women with ovarian aging. It will also learn about the safety of Vitamin C. The main questions it aims to answer are: * Does Vitamin C supplementation improve the ovarian reserve prediction score? * What medical problems do participants have when taking Vitamin C supplementation? Researchers will compare Vitamin C to a placebo (a look-alike substance that contains no drug) to see if drug Vitamin C works to improve ovarian reserve in women with ovarian aging. Participants will: * Take Vitamin C or a placebo every day for 12 months * Visit the clinic once every 4 weeks for follow-up and drug distribution. * Return the Vitamin C box at each visit. * Report any adverse effects of treatment to the doctor. * Fill out a questionnaire at each visit. * After 6 months and 12 months of intervention, take blood test and ultrasonic examination.","overall_status":"Not Yet Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Peking University Third Hospital","enrollment":354,"countries":[],"start_date":"2025-07-02","completion_date":"2027-08-31","last_update_date":"2025-06-26","source_url":"https://clinicaltrials.gov/study/NCT06794060","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Not Yet Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:18.765619+00:00","last_seen_at":"2026-09-25T06:15:10.83+00:00","metadata":{"sex":"FEMALE","acronym":null,"age_range":null,"comparator":"Placebo","organization":"Peking University Third Hospital","interventions":["Vitamin C (Ascorbic Acid)","Placebo"],"registry_source":"ClinicalTrials.gov","outcome_measures":["ovarian reserve prediction score — 1 year","FSH level — 1 year","AMH level — 12 months","AFC — 12 months","Clinical pregnancy rate — 12 months","Time to pregnancy — 12 months","Livebirth rate — 12 months"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · TRIPLE","source_has_results":false},"controlled_terms":["Premature Ovarian Insufficiency","Ovarian Reserve Function","Vitamin C (Ascorbic Acid)","Placebo"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: ovarian aging.","quality_checked_at":"2026-09-25T06:15:11.94354+00:00","duplicate_cluster_key":"id:nct06794060","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-07-02 to 2027-08-31","comparator":"Placebo","confidence":"structured-source","population":"FEMALE","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:10.838Z","intervention":["Vitamin C (Ascorbic Acid)","Placebo"],"participants":354,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · TRIPLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["ovarian reserve prediction score — 1 year","FSH level — 1 year","AMH level — 12 months","AFC — 12 months","Clinical pregnancy rate — 12 months","Time to pregnancy — 12 months","Livebirth rate — 12 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"ovarian-aging","is_published":true,"match_reasons":["Title contains controlled term: ovarian aging.","Abstract contains controlled term: ovarian aging, ovarian reserve.","Source terminology contains: ovarian reserve.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Ovarian ageing","slug":"ovarian-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/22409","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}