{"type":"trials","record":{"id":22438,"source_id":"clinicaltrials-gov","external_id":"NCT07361887","title":"Deciphering the Effect of Moderate Wine Consumption on Healthy Aging Through Postprandial Extracellular Vesicles.","brief_summary":"This study aims to investigate how moderate wine consumption influences circulating extracellular vesicles (EVs) in healthy adults. EVs are small particles released by cells that carry proteins, lipids, and genetic material, and play important roles in communication between cells. Participants will consume a single serving of red or white wine, and blood samples will be collected before and after consumption to study changes in the composition and function of EVs. The study will also assess how these EVs affect vascular, immune, and brain-related cells. The results are expected to improve our understanding of how moderate wine intake contributes to cardiovascular and brain health.","overall_status":"Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University of Seville","enrollment":8,"countries":["Spain"],"start_date":"2025-11-01","completion_date":"2027-03-31","last_update_date":"2026-01-23","source_url":"https://clinicaltrials.gov/study/NCT07361887","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:19.146275+00:00","last_seen_at":"2026-09-25T06:20:09.878+00:00","metadata":{"sex":"ALL","acronym":"(WINEVOME)","age_range":"35 Years to 36 Years","comparator":"Water (Control)","organization":"University of Seville","interventions":["White Wine","Red Wine","Water"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Concentration of circulating extracellular vesicles — Baseline (0 hours), postprandial peak (2 hours after beverage int…","Mean size of circulating extracellular vesicles — Baseline (0 hours), postprandial peak (2 hours after beverage intake)…","Postprandial changes in extracellular vesicle proteome — Baseline (0 hours), postprandial peak (2 hours after beverage…","Postprandial changes in extracellular vesicle lipidome — Baseline (0 hours), postprandial peak (2 hours after beverage…","Change from baseline in plasma glucose concentration — Baseline (0 hours), 2 hours, and 6 hours after beverage intake","Change from baseline in plasma insulin concentration — Baseline (0 hours), 2 hours, and 6 hours after beverage intake","Change from baseline in plasma triglyceride concentration — Baseline (0 hours), 2 hours, and 6 hours after beverage int…","Change from baseline in plasma total cholesterol concentration — Baseline (0 hours), 2 hours, and 6 hours after beverag…","Change from baseline in plasma HDL cholesterol concentration — Baseline (0 hours), 2 hours, and 6 hours after beverage…","Change from baseline in plasma LDL cholesterol concentration — Baseline (0 hours), 2 hours, and 6 hours after beverage…","Change from baseline in plasma interleukin-6 (IL-6) concentration — Baseline (0 hours), 2 hours, and 6 hours after beve…","Change from baseline in plasma tumor necrosis factor alpha (TNF-α) concentration — Baseline (0 hours), 2 hours, and 6 h…","Change from baseline in plasma interleukin-1 beta (IL-1β) concentration — Baseline (0 hours), 2 hours, and 6 hours afte…","Change from baseline in plasma monocyte chemoattractant protein-1 (MCP-1/CCL2) concentration — Baseline (0 hours), 2 ho…","Transendothelial electrical resistance (TEER) in an in vitro human blood-brain barrier model after exposure to postpran…","Claudin-5 (CLDN5) protein expression in an in vitro human blood-brain barrier model after exposure to postprandial extr…","Occludin (OCLN) protein expression in an in vitro human blood-brain barrier model after exposure to postprandial extrac…","Interleukin-6 (IL-6) concentration in microglial culture supernatant after exposure to postprandial extracellular vesic…","Tumor necrosis factor alpha (TNF-α) concentration in microglial culture supernatant after exposure to postprandial extr…","IL1B mRNA expression in microglia after exposure to postprandial extracellular vesicles — EVs isolated at baseline (0 h…"],"design_description":"RANDOMIZED · CROSSOVER · BASIC SCIENCE · SINGLE","source_has_results":false},"controlled_terms":["Atherosclerosis Cardiovascular Disease","Obesity","Metabolic Syndrome","Metabolic Disorders","Inflammation","Neurodegeneration","Neurodegenerative Disease","Alzheimer s Disease","White Wine","Red Wine","Water"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":85,"publication_state":"published","match_explanation":"Title contains controlled term: extracellular vesicle.","quality_checked_at":"2026-09-25T06:20:11.344357+00:00","duplicate_cluster_key":"id:nct07361887","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-11-01 to 2027-03-31","comparator":"Water (Control)","confidence":"structured-source","population":"ALL · 35 Years to 36 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:09.890Z","intervention":["White Wine","Red Wine","Water"],"participants":8,"study_design":"RANDOMIZED · CROSSOVER · BASIC SCIENCE · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Concentration of circulating extracellular vesicles — Baseline (0 hours), postprandial peak (2 hours after beverage int…","Mean size of circulating extracellular vesicles — Baseline (0 hours), postprandial peak (2 hours after beverage intake)…","Postprandial changes in extracellular vesicle proteome — Baseline (0 hours), postprandial peak (2 hours after beverage…","Postprandial changes in extracellular vesicle lipidome — Baseline (0 hours), postprandial peak (2 hours after beverage…","Change from baseline in plasma glucose concentration — Baseline (0 hours), 2 hours, and 6 hours after beverage intake","Change from baseline in plasma insulin concentration — Baseline (0 hours), 2 hours, and 6 hours after beverage intake","Change from baseline in plasma triglyceride concentration — Baseline (0 hours), 2 hours, and 6 hours after beverage int…","Change from baseline in plasma total cholesterol concentration — Baseline (0 hours), 2 hours, and 6 hours after beverag…","Change from baseline in plasma HDL cholesterol concentration — Baseline (0 hours), 2 hours, and 6 hours after beverage…","Change from baseline in plasma LDL cholesterol concentration — Baseline (0 hours), 2 hours, and 6 hours after beverage…","Change from baseline in plasma interleukin-6 (IL-6) concentration — Baseline (0 hours), 2 hours, and 6 hours after beve…","Change from baseline in plasma tumor necrosis factor alpha (TNF-α) concentration — Baseline (0 hours), 2 hours, and 6 h…","Change from baseline in plasma interleukin-1 beta (IL-1β) concentration — Baseline (0 hours), 2 hours, and 6 hours afte…","Change from baseline in plasma monocyte chemoattractant protein-1 (MCP-1/CCL2) concentration — Baseline (0 hours), 2 ho…","Transendothelial electrical resistance (TEER) in an in vitro human blood-brain barrier model after exposure to postpran…","Claudin-5 (CLDN5) protein expression in an in vitro human blood-brain barrier model after exposure to postprandial extr…","Occludin (OCLN) protein expression in an in vitro human blood-brain barrier model after exposure to postprandial extrac…","Interleukin-6 (IL-6) concentration in microglial culture supernatant after exposure to postprandial extracellular vesic…","Tumor necrosis factor alpha (TNF-α) concentration in microglial culture supernatant after exposure to postprandial extr…","IL1B mRNA expression in microglia after exposure to postprandial extracellular vesicles — EVs isolated at baseline (0 h…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"intercellular-communication","is_published":true,"match_reasons":["Title contains controlled term: extracellular vesicle.","Abstract contains controlled term: extracellular vesicle.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Intercellular communication","slug":"intercellular-communication"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/22438","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}