{"type":"trials","record":{"id":22454,"source_id":"clinicaltrials-gov","external_id":"NCT07643675","title":"Glycine Supplementation Improves Cognitive Performance in Mexican Older Adults","brief_summary":"The purpose of this study was to evaluate the effects of daily glycine supplementation on metabolic health and cognitive performance in older adults. Over a period of six months, participants received 1,000 mg of glycine per day to determine if this amino acid could improve markers of insulin resistance, glucose metabolism, and cognitive functions such as memory and executive tasks. The research aimed to identify whether this nutritional intervention provides a safe and effective strategy to support healthy aging, focusing on the link between metabolic balance and brain health in the elderly population.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Brenda Sarahí Beristain Lujano","enrollment":59,"countries":["Mexico"],"start_date":"2024-12-01","completion_date":"2025-12-01","last_update_date":"2026-06-15","source_url":"https://clinicaltrials.gov/study/NCT07643675","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:23.31052+00:00","last_seen_at":"2026-09-25T06:05:53.058+00:00","metadata":{"sex":"ALL","acronym":"Glycine","age_range":"60 Years to 80 Years","comparator":null,"organization":"Escuela Superior de Medicina","interventions":["Glycine"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Brain-Derived Neurotrophic Factor (BDNF) levels — Baseline (T0), 3 months (T3) and 6 months (T6)","Cognitive performance evaluated by the Cognitive performance was assessed using the Montreal Cognitive Assessment (MoCA…"],"design_description":"NA · SINGLE GROUP · SUPPORTIVE CARE · NONE","source_has_results":false},"controlled_terms":["Older Adults With Cognitive Decline","Insulin Resistance Syndrome","Aging","Glycine"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: glycine.","quality_checked_at":"2026-09-25T06:05:53.517814+00:00","duplicate_cluster_key":"id:nct07643675","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2024-12-01 to 2025-12-01","comparator":null,"confidence":"structured-source","population":"ALL · 60 Years to 80 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:05:53.059Z","intervention":["Glycine"],"participants":59,"study_design":"NA · SINGLE GROUP · SUPPORTIVE CARE · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Brain-Derived Neurotrophic Factor (BDNF) levels — Baseline (T0), 3 months (T3) and 6 months (T6)","Cognitive performance evaluated by the Cognitive performance was assessed using the Montreal Cognitive Assessment (MoCA…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"glycine-glynac","is_published":true,"match_reasons":["Title contains controlled term: glycine.","Abstract contains controlled term: glycine.","Source terminology contains: glycine.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Glycine and GlyNAC","slug":"glycine-glynac"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/22454","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}