{"type":"trials","record":{"id":22542,"source_id":"clinicaltrials-gov","external_id":"NCT06980896","title":"Physical Activity Oxidative Stress and Inflammation With Ageing","brief_summary":"Sarcopenia, an age-related decline in muscle function, are thought to be influenced by oxidative stress and low-grade inflammation, resulting in significant muscle mass reduction and altered physical performance. Indeed, oxidative stress and chronic inflammation in older adults are key factors contributing to metabolic protein disturbances, DNA mutations, and skeletal muscle decline during aging. Additionally, reduced food intake can lead to malnutrition, exacerbating muscle protein loss, oxidative stress and chronic inflammation. Recent research has shown that a nutritional intervention, i.e. antioxidant supplementation (e.g., vitamins C, E, zinc, selenium) can reduce muscle damage in Facioscapulohumeral Dystrophy (FSHD) by correcting mitochondrial dysfunction and inflammation with a beneficial effect on physical performance and have led to the development of a personalized antioxidant supplementation model, supported by clinical trials (NCT02622438). Although antioxidant supplementation appears beneficial for FSHD patients, its effects on age-related muscle decline remain unclear. This study aims to explore correlation between oxidative stress, inflammation, nutritional status and physical performance in older individuals. The findings will help establish the physiological basis for a potential antioxidant therapy for age-related muscle deterioration.","overall_status":"Not Yet Recruiting","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Nantes University Hospital","enrollment":30,"countries":["France"],"start_date":"2025-09-01","completion_date":"2027-05-01","last_update_date":"2025-05-20","source_url":"https://clinicaltrials.gov/study/NCT06980896","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Not Yet Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T02:17:02.944409+00:00","last_seen_at":"2026-09-25T06:15:54.38+00:00","metadata":{"sex":"ALL","acronym":"POXI-AGEING","age_range":"70 Years to 90 Years","comparator":null,"organization":"Nantes University Hospital","interventions":[],"registry_source":"ClinicalTrials.gov","outcome_measures":["Correlations between VitC/VitE and Cu/Zn ratios, selenium, and muscle strength — 8 months","Investigate correlations between biomarkers involved directly or indirectly in the oxidative stress process and muscle…","Investigate correlations between biomarkers involved directly or indirectly in the oxidative stress process and physica…","Investigate correlations between biomarkers involved directly or indirectly in the oxidative stress process and inflamm…","Investigate correlations between biomarkers involved directly or indirectly in the oxidative stress process and the nut…","Investigate correlations between inflammation-related biomarkers and muscle strength in the included patients. — 8 mont…","Investigate correlations between inflammation-related biomarkers and muscle power in the included patients. — 8 months","Investigate correlations between inflammation-related biomarkers and muscle mass in the included patients. — 8 months","Investigate correlations between inflammation-related biomarkers and physical performance in the included patients. — 8…","Investigate correlations between inflammation-related biomarkers and the nutritional intake of the included patients. —…","Investigate correlations between nutritional intake and physical performance in the included patients. — 8 months","Investigate correlations between muscle mass and physical performance in the included patients. — 8 months"],"design_description":null,"source_has_results":false},"controlled_terms":["Inflammation","Oxydative Stress","Sarcopenia","Older Patient","Ageing"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: oxidative stress.","quality_checked_at":"2026-09-25T06:16:07.48358+00:00","duplicate_cluster_key":"id:nct06980896","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-09-01 to 2027-05-01","comparator":null,"confidence":"structured-source","population":"ALL · 70 Years to 90 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:54.439Z","intervention":[],"participants":30,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Correlations between VitC/VitE and Cu/Zn ratios, selenium, and muscle strength — 8 months","Investigate correlations between biomarkers involved directly or indirectly in the oxidative stress process and muscle…","Investigate correlations between biomarkers involved directly or indirectly in the oxidative stress process and physica…","Investigate correlations between biomarkers involved directly or indirectly in the oxidative stress process and inflamm…","Investigate correlations between biomarkers involved directly or indirectly in the oxidative stress process and the nut…","Investigate correlations between inflammation-related biomarkers and muscle strength in the included patients. — 8 mont…","Investigate correlations between inflammation-related biomarkers and muscle power in the included patients. — 8 months","Investigate correlations between inflammation-related biomarkers and muscle mass in the included patients. — 8 months","Investigate correlations between inflammation-related biomarkers and physical performance in the included patients. — 8…","Investigate correlations between inflammation-related biomarkers and the nutritional intake of the included patients. —…","Investigate correlations between nutritional intake and physical performance in the included patients. — 8 months","Investigate correlations between muscle mass and physical performance in the included patients. — 8 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"oxidative-stress","is_published":true,"match_reasons":["Title contains controlled term: oxidative stress.","Abstract contains controlled term: oxidative stress.","Title supplies longevity context: ageing.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Oxidative stress","slug":"oxidative-stress"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/22542","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}