{"type":"trials","record":{"id":22681,"source_id":"clinicaltrials-gov","external_id":"NCT02116166","title":"Skeletal Muscle Inflammation, Oxidative Stress and DNA Repair in Age-Related Sarcopenia","brief_summary":"The purpose of this research study is to investigate how and why the loss of muscle mass occurs with aging. Tissue collected from young subjects will be compared to previously collected tissue from elderly subjects, as well as previously collected data on muscle function/mass to further investigate cellular and molecular pathways that have recently been shown to be important for the aging process in muscle. The Principal Investigator (PI) and the study team will look for specific proteins (called biomarkers) that can be present in the muscle tissue in various amounts in different individuals. This study will increase the investigators understanding of the processes of muscle atrophy (loss of mass) and functional loss at older age and will help to find new treatments and interventions aimed at improving the quality of life and independence of America's rapidly expanding elderly population.","overall_status":"Completed","phases":[],"study_type":"OBSERVATIONAL","sponsor":"University of Florida","enrollment":10,"countries":["United States"],"start_date":"2014-05-01","completion_date":"2016-07-01","last_update_date":"2018-04-05","source_url":"https://clinicaltrials.gov/study/NCT02116166","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T03:17:05.484536+00:00","last_seen_at":"2026-09-25T06:15:54.38+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"20 Years to 35 Years","comparator":null,"organization":"University of Florida","interventions":[],"registry_source":"ClinicalTrials.gov","outcome_measures":["Tumor Necrosis Factor alpha (TNF-alpha) — baseline","tumor-necrosis factor receptor-1 (TNFR1) — baseline","Phospho-Inhibitory Subunit Of NF-KBα (pIkBα) — baseline","Chemokine (C-C motif) ligand 2 (CCL2) — baseline","zinc transporter (ZIP) 14 — baseline","Interleukin 6 (IL-6) — baseline","Interleukin (IL) 11β — baseline","Interleukin 8 (IL-8) — baseline","C-C chemokine receptor type 2 (CCR2) — baseline","zinc transporter 14 (ZIP14) — baseline","copper — baseline","zinc — baseline","iron — baseline","ribosome profiling — baseline"],"design_description":null,"source_has_results":false},"controlled_terms":["Sarcopenia"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: sarcopenia.","quality_checked_at":"2026-09-25T06:16:07.48358+00:00","duplicate_cluster_key":"id:nct02116166","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2014-05-01 to 2016-07-01","comparator":null,"confidence":"structured-source","population":"ALL · 20 Years to 35 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:54.489Z","intervention":[],"participants":10,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Tumor Necrosis Factor alpha (TNF-alpha) — baseline","tumor-necrosis factor receptor-1 (TNFR1) — baseline","Phospho-Inhibitory Subunit Of NF-KBα (pIkBα) — baseline","Chemokine (C-C motif) ligand 2 (CCL2) — baseline","zinc transporter (ZIP) 14 — baseline","Interleukin 6 (IL-6) — baseline","Interleukin (IL) 11β — baseline","Interleukin 8 (IL-8) — baseline","C-C chemokine receptor type 2 (CCR2) — baseline","zinc transporter 14 (ZIP14) — baseline","copper — baseline","zinc — baseline","iron — baseline","ribosome profiling — baseline"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"genomic-instability","is_published":true,"match_reasons":["Title contains controlled term: dna repair.","Title supplies longevity context: age-related.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Genomic instability","slug":"genomic-instability"}},{"topic_slug":"oxidative-stress","is_published":true,"match_reasons":["Title contains controlled term: oxidative stress.","Title supplies longevity context: age-related.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Oxidative stress","slug":"oxidative-stress"}},{"topic_slug":"sarcopenia","is_published":true,"match_reasons":["Title contains controlled term: sarcopenia.","Source terminology contains: sarcopenia.","Title supplies longevity context: age-related.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Sarcopenia","slug":"sarcopenia"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/22681","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}