{"type":"trials","record":{"id":22683,"source_id":"clinicaltrials-gov","external_id":"NCT03272867","title":"Effect of an Anti-ageing Supplement on Oxidative Stress","brief_summary":"This pilot study serves to investigate whether ProManna intake leads to any changes in baseline levels for oxidative stress markers. In addition, biomarker responses following oxidative stress challenge tests will be assessed in subjects taking ProManna versus placebo supplements.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University Medical Center Groningen","enrollment":20,"countries":["Netherlands"],"start_date":"2014-12-01","completion_date":"2016-06-01","last_update_date":"2017-09-06","source_url":"https://clinicaltrials.gov/study/NCT03272867","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T03:17:05.484536+00:00","last_seen_at":"2026-09-25T06:15:54.38+00:00","metadata":{"sex":"ALL","acronym":"PromAge","age_range":"60 Years to 70 Years","comparator":"Control group","organization":"University Medical Center Groningen","interventions":["ProManna"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Changes in oxidative stress markers — Two weeks","Changes in oxidative stress following a hyperoxia or glucose challenge — Two weeks","Changes in experienced health — Two weeks"],"design_description":"RANDOMIZED · CROSSOVER · PREVENTION · QUADRUPLE","source_has_results":false},"controlled_terms":["Healthy Volunteers","Age Group: 60-70","Overweight","ProManna"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: oxidative stress.","quality_checked_at":"2026-09-25T06:16:07.48358+00:00","duplicate_cluster_key":"id:nct03272867","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2014-12-01 to 2016-06-01","comparator":"Control group","confidence":"structured-source","population":"ALL · 60 Years to 70 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:54.491Z","intervention":["ProManna"],"participants":20,"study_design":"RANDOMIZED · CROSSOVER · PREVENTION · QUADRUPLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Changes in oxidative stress markers — Two weeks","Changes in oxidative stress following a hyperoxia or glucose challenge — Two weeks","Changes in experienced health — Two weeks"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"oxidative-stress","is_published":true,"match_reasons":["Title contains controlled term: oxidative stress.","Abstract contains controlled term: oxidative stress.","Title supplies longevity context: ageing.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Oxidative stress","slug":"oxidative-stress"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/22683","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}