{"type":"trials","record":{"id":249,"source_id":"clinicaltrials-gov","external_id":"NCT05488652","title":"Cerebromicrovascular Effects of Time-Restricted Eating in Older Adults","brief_summary":"The central hypothesis of this study is that closer adherence to time restricted eating (TRE) will improve endothelial function, neurovascular (NVC) responses, resulting in improved cognitive performance, potentially through activation of SIRT1-dependent vasoprotective pathways.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University of Oklahoma","enrollment":11,"countries":["United States"],"start_date":"2022-11-17","completion_date":"2024-01-10","last_update_date":"2026-08-17","source_url":"https://clinicaltrials.gov/study/NCT05488652","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-14T02:45:01.944738+00:00","last_seen_at":"2026-09-25T06:25:43.79+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"21 Years","comparator":null,"organization":"University of Oklahoma","interventions":["Time restricted eating"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Neurovascular Coupling Using Functional Near Infrared Spectroscopy (fNIRS) — Baseline, 6 months","Neurovascular Coupling Using the Dynamic Retinal Vessel Analysis — Baseline, 6 months","Neurovascular Coupling Using Transcranial Doppler — Baseline, 6 months","Microvascular Endothelial Function — Baseline, 6 months","Macrovascular Endothelial Function — Baseline, 6 months","Deep Tissue Oxygen Saturation — Baseline, 6 months","Arterial Stiffness — Baseline, 6 months","ECG — Baseline, 6 months","Glycocalyx - Perfused Boundary Region — Baseline, 6 months","Capillary Density — Baseline, 6 months","Red Blood Cell Velocity — Baseline, 6 months","Inhibitory Control and Attention — Baseline, 6 months","Episodic Memory — Baseline, 6 months","Working Memory — Baseline, 6 months","Language — Baseline, 6 months","Executive Function — Baseline, 6 months","Processing Speed — Baseline, 6 months"],"design_description":"NA · SINGLE GROUP · OTHER · NONE","source_has_results":true},"controlled_terms":["Time Restricted Eating","Time restricted eating"],"relevance_confidence":80,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: time-restricted eating.","quality_checked_at":"2026-09-25T06:25:44.537089+00:00","duplicate_cluster_key":"id:nct05488652","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2022-11-17 to 2024-01-10","comparator":null,"confidence":"structured-source","population":"ALL · 21 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:25:43.793Z","intervention":["Time restricted eating"],"participants":11,"study_design":"NA · SINGLE GROUP · OTHER · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Neurovascular Coupling Using Functional Near Infrared Spectroscopy (fNIRS) — Baseline, 6 months","Neurovascular Coupling Using the Dynamic Retinal Vessel Analysis — Baseline, 6 months","Neurovascular Coupling Using Transcranial Doppler — Baseline, 6 months","Microvascular Endothelial Function — Baseline, 6 months","Macrovascular Endothelial Function — Baseline, 6 months","Deep Tissue Oxygen Saturation — Baseline, 6 months","Arterial Stiffness — Baseline, 6 months","ECG — Baseline, 6 months","Glycocalyx - Perfused Boundary Region — Baseline, 6 months","Capillary Density — Baseline, 6 months","Red Blood Cell Velocity — Baseline, 6 months","Inhibitory Control and Attention — Baseline, 6 months","Episodic Memory — Baseline, 6 months","Working Memory — Baseline, 6 months","Language — Baseline, 6 months","Executive Function — Baseline, 6 months","Processing Speed — Baseline, 6 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"caloric-restriction","is_published":true,"match_reasons":["Title contains controlled term: time-restricted eating.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Caloric restriction","slug":"caloric-restriction"}},{"topic_slug":"time-restricted-eating","is_published":true,"match_reasons":["Title contains controlled term: time-restricted eating.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Time-restricted eating","slug":"time-restricted-eating"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/249","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}