{"type":"trials","record":{"id":259,"source_id":"clinicaltrials-gov","external_id":"NCT06548191","title":"TREAD: Time Restricted Eating Intervention for Alzheimer's Disease","brief_summary":"The goal of this clinical trial is to learn if restricting the time of eating to allow for prolonged fasting at night may reduce sleep disturbances, cognitive decay, and pathology in patients diagnosed with Mild Cognitive Impairment (MCI) or early to moderate Alzheimer's disease (AD). It will also learn about the feasibility of practicing 14 h of nightly fasting in this group of older adults. The main questions it aims to answer are: * Does prolonged nightly fasting of 14 h can reduce markers of AD pathology and aging and reduce cognitive and sleep alterations in MCI and AD patients? * Can patients with MCI and early /moderate AD sustain time-restricted eating for 3 to 6 months? Researchers will compare participants who fast for 14 h per night during 3 months to those who fast for less than 12 h/night. Researchers will also compare participants that fast for 3 months to those who fast d…","overall_status":"Recruiting","phases":["PHASE1"],"study_type":"INTERVENTIONAL","sponsor":"University of California, San Diego","enrollment":60,"countries":["United States"],"start_date":"2025-04-23","completion_date":"2027-06-30","last_update_date":"2026-05-26","source_url":"https://clinicaltrials.gov/study/NCT06548191","editorial_summary":"A registered PHASE1 study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-14T02:45:01.944738+00:00","last_seen_at":"2026-09-15T00:18:34.37+00:00","metadata":{"acronym":"TREAD","organization":"University of California, San Diego","source_has_results":false},"controlled_terms":[],"relevance_confidence":68,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Published automatically with 68% topic confidence after controlled-term evaluation.","quality_checked_at":"2026-09-15T02:15:56.576005+00:00","duplicate_cluster_key":"registry:nct06548191","duplicate_of_id":null,"clinical_trial_topics":[{"topic_slug":"caloric-restriction","is_published":true,"match_reasons":["Legacy trial evaluated automatically against controlled title, summary, and longevity-context rules."],"matched_fields":["abstract"],"relevance_score":68,"intelligence_topics":{"name":"Caloric restriction","slug":"caloric-restriction"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/259","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}