{"type":"trials","record":{"id":26,"source_id":"clinicaltrials-gov","external_id":"NCT04608448","title":"Topical-RAPA Use in Inflammation Reversal and Re-setting the Epigenetic Clock","brief_summary":"Topical Rapamycin ointment will be applied to participant forearms to test whether epigenetic changes in the skin are elicited.","overall_status":"Completed","phases":["EARLY_PHASE1"],"study_type":"INTERVENTIONAL","sponsor":"The University of Texas Health Science Center at San Antonio","enrollment":22,"countries":["United States"],"start_date":"2021-04-28","completion_date":"2022-04-15","last_update_date":"2023-07-19","source_url":"https://clinicaltrials.gov/study/NCT04608448","editorial_summary":"A registered EARLY_PHASE1 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-14T02:44:58.543517+00:00","last_seen_at":"2026-09-25T06:05:22.821+00:00","metadata":{"sex":"ALL","acronym":"Topical-RAPA","age_range":"65 Years to 95 Years","comparator":"Topical Rapamycin; Placebo","organization":"The University of Texas Health Science Center at San Antonio","interventions":["Rapamycin Topical Ointment","Placebo"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in Epigenetic Markers — Baseline to 6 months","Change in Inflammatory Marker IL-6 — Baseline to 6 months","Change in Inflammatory Marker CRP — Baseline to 6 months"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · DOUBLE","source_has_results":true},"controlled_terms":["Aging","Epigenetics","Inflammatory Mediators","Rapamycin Topical Ointment","Placebo"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Abstract contains controlled term: rapamycin.","quality_checked_at":"2026-09-25T06:05:25.247365+00:00","duplicate_cluster_key":"id:nct04608448","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2021-04-28 to 2022-04-15","comparator":"Topical Rapamycin; Placebo","confidence":"structured-source","population":"ALL · 65 Years to 95 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:05:22.848Z","intervention":["Rapamycin Topical Ointment","Placebo"],"participants":22,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"EARLY_PHASE1","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in Epigenetic Markers — Baseline to 6 months","Change in Inflammatory Marker IL-6 — Baseline to 6 months","Change in Inflammatory Marker CRP — Baseline to 6 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"epigenetic-clocks","is_published":true,"match_reasons":["Title contains controlled term: epigenetic clock.","Source terminology supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","controlled context","study type"],"relevance_score":70,"intelligence_topics":{"name":"Epigenetic clocks","slug":"epigenetic-clocks"}},{"topic_slug":"rapamycin","is_published":true,"match_reasons":["Abstract contains controlled term: rapamycin.","Source terminology contains: rapamycin.","Source terminology supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["abstract","controlled terminology","controlled context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Rapamycin","slug":"rapamycin"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/26","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}