{"type":"trials","record":{"id":267,"source_id":"clinicaltrials-gov","external_id":"NCT05880095","title":"Healthy Aging Through Time- Restricted Eating in Adults With Overweight/Obesity and Incipient Liver Disease: ENSATI","brief_summary":"The goal of this clinical trial is to evaluate the effect of a time-restricted eating (TRE) regimen on hallmarks of aging, in comparison with traditional caloric restriction and an unrestricted diet in adults with overweight/obesity. Investigators aim to assess: 1. If TRE is sustainable over 6-months. 2. If TRE positively affects metabolism and body composition 3. If TRE improves circadian rhythm/sleep. 4. If TRE benefits cognitive function, mood and quality of life (QoL). 5. If these beneficial effects are associated with changes in molecular hallmarks of aging. Participants will be randomly allocated to: * an unrestricted Mediterranean diet group (MedD) * a energy-reduced Mediterranean diet group (MedD\\_RC) * or to an unrestricted Mediterranean diet with TRE group (MedD\\_TRE) Intervention will be maintained for 6 months, and there will be an additional 6-months period of follow-up to…","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"IMDEA Food","enrollment":176,"countries":["Spain"],"start_date":"2023-07-05","completion_date":"2026-03-15","last_update_date":"2026-03-27","source_url":"https://clinicaltrials.gov/study/NCT05880095","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-14T02:45:01.944738+00:00","last_seen_at":"2026-09-15T00:18:34.37+00:00","metadata":{"acronym":"ENSATI","organization":"IMDEA Food","source_has_results":false},"controlled_terms":[],"relevance_confidence":68,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Published automatically with 68% topic confidence after controlled-term evaluation.","quality_checked_at":"2026-09-15T02:15:56.576005+00:00","duplicate_cluster_key":"registry:nct05880095","duplicate_of_id":null,"clinical_trial_topics":[{"topic_slug":"caloric-restriction","is_published":true,"match_reasons":["Legacy trial evaluated automatically against controlled title, summary, and longevity-context rules."],"matched_fields":["abstract"],"relevance_score":68,"intelligence_topics":{"name":"Caloric restriction","slug":"caloric-restriction"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/267","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}