{"type":"trials","record":{"id":27695,"source_id":"clinicaltrials-gov","external_id":"NCT07118423","title":"Effects of Resistance Training in Centenarians","brief_summary":"This study is a multicenter intervention evaluating the effectiveness and safety of resistance training in institutionalized centenarians. The aim of the study is to analyze the effects of 12 weeks of resistance training on frailty, muscle power, physical function, strength, functional independence, physical activity, cardiovascular health, cognitive function, and quality of life in adults aged 100 and over living in nursing homes.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Universidad de Zaragoza","enrollment":19,"countries":["Spain"],"start_date":"2019-01-08","completion_date":"2020-03-31","last_update_date":"2025-08-12","source_url":"https://clinicaltrials.gov/study/NCT07118423","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T23:18:16.628904+00:00","last_seen_at":"2026-09-25T06:15:12.989+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"100 Years","comparator":"Control group","organization":"Universidad de Zaragoza","interventions":["Exercise"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Frailty using Fried's Frailty Criteria — T0 (baseline) and T1 (post 12 weeks)","Frailty using Frailty Trait Scale - Short Form — T0 (baseline) and T1 (post 12 weeks)","Muscle power — T0 (baseline) and T1 (post 12 weeks)","Physical function based on the Short Physical Performance Battery — T0 (baseline) and T1 (post 12 weeks)","Physical function using Physical Performance Mobility Examination. — T0 (baseline) and T1 (post 12 weeks)","Physical function based on the gait speed in 6 meters. — T0 (baseline) and T1 (post 12 weeks)","Physical function using the Time Up and Go test. — T0 (baseline) and T1 (post 12 weeks)","Cognitive function using Mini Mental State Examination. — T0 (baseline) and T1 (post 12 weeks)","Cognitive function using the animal naming test within 1 minute. — T0 (baseline) and T1 (post 12 weeks)","Cognitive function using the clock drawing test. — T0 (baseline) and T1 (post 12 weeks)","Quality of life using EuroQoL-5 Dimension questionnaire. — T0 (baseline) and T1 (post 12 weeks)","Quality of life using Visual Analog Scale. — T0 (baseline) and T1 (post 12 weeks)","Isometric muscle strength — T0 (baseline) and T1 (post 12 weeks)","Disability — T0 (baseline) and T1 (post 12 weeks)","Accelerometer-based physical activity — T0 (baseline) and T1 (post 12 weeks)","Falls — T0 (baseline) and T1 (post 12 weeks)","Heart rate variability indices from electrocardiogram (ECG) — T0 (baseline) and T1 (post 12 weeks)","Blood pressure — T0 (baseline) and T1 (post 12 weeks)","Ankle-brachial index relate to blood pressure — T0 (baseline) and T1 (post 12 weeks)","Albumin — T0 (baseline) and T1 (post 12 weeks)"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · NONE","source_has_results":false},"controlled_terms":["Frailty","Muscle Power","Old and Very Old People","Cognitive Abilities","Physical Activity","Exercise"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: centenarian.","quality_checked_at":"2026-09-25T06:15:13.224785+00:00","duplicate_cluster_key":"id:nct07118423","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2019-01-08 to 2020-03-31","comparator":"Control group","confidence":"structured-source","population":"ALL · 100 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:12.991Z","intervention":["Exercise"],"participants":19,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Frailty using Fried's Frailty Criteria — T0 (baseline) and T1 (post 12 weeks)","Frailty using Frailty Trait Scale - Short Form — T0 (baseline) and T1 (post 12 weeks)","Muscle power — T0 (baseline) and T1 (post 12 weeks)","Physical function based on the Short Physical Performance Battery — T0 (baseline) and T1 (post 12 weeks)","Physical function using Physical Performance Mobility Examination. — T0 (baseline) and T1 (post 12 weeks)","Physical function based on the gait speed in 6 meters. — T0 (baseline) and T1 (post 12 weeks)","Physical function using the Time Up and Go test. — T0 (baseline) and T1 (post 12 weeks)","Cognitive function using Mini Mental State Examination. — T0 (baseline) and T1 (post 12 weeks)","Cognitive function using the animal naming test within 1 minute. — T0 (baseline) and T1 (post 12 weeks)","Cognitive function using the clock drawing test. — T0 (baseline) and T1 (post 12 weeks)","Quality of life using EuroQoL-5 Dimension questionnaire. — T0 (baseline) and T1 (post 12 weeks)","Quality of life using Visual Analog Scale. — T0 (baseline) and T1 (post 12 weeks)","Isometric muscle strength — T0 (baseline) and T1 (post 12 weeks)","Disability — T0 (baseline) and T1 (post 12 weeks)","Accelerometer-based physical activity — T0 (baseline) and T1 (post 12 weeks)","Falls — T0 (baseline) and T1 (post 12 weeks)","Heart rate variability indices from electrocardiogram (ECG) — T0 (baseline) and T1 (post 12 weeks)","Blood pressure — T0 (baseline) and T1 (post 12 weeks)","Ankle-brachial index relate to blood pressure — T0 (baseline) and T1 (post 12 weeks)","Albumin — T0 (baseline) and T1 (post 12 weeks)"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"centenarian-biology","is_published":true,"match_reasons":["Title contains controlled term: centenarian.","Abstract contains controlled term: centenarian.","Title supplies longevity context: centenarian.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Centenarian biology","slug":"centenarian-biology"}},{"topic_slug":"resistance-training","is_published":true,"match_reasons":["Title contains controlled term: resistance training.","Abstract contains controlled term: resistance training.","Title supplies longevity context: centenarian.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Resistance training","slug":"resistance-training"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/27695","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}