{"type":"trials","record":{"id":27699,"source_id":"clinicaltrials-gov","external_id":"NCT05701371","title":"BACTERIA ISOLATION FROM STOOLS COLLECTED FROM CENTENARIANS PEOPLE","brief_summary":"The compositional analysis of commensal bacterial populations collected from a variety of clinical samples has been recently made possible with the availability of Next Generation Sequencing (NGS) technologies. The term 'next-generation probiotics' (NGP) is now widely used to describe these commensal species of potential health interest. However, this approach is still hampered by the fact that there are usually few or even no strains available for a number of commensal species. In this context, BIOASTER has developed a specific technological process based on flow cytometry analysis and then sorting under strictly anaerobic conditions to target and cultivate commensal species of interest. The review of the literature shows that certain species present among centenarians have an interest in maintaining the longevity of these individuals. Numerous studies have shown that the intestinal microbiota of centenarians presents a greater diversity compared to groups of younger subjects as well as an enrichment in certain bacteria such as Akkermansia and Christensenella. The goal of this observational study is to constitute a biological samples collection from centenarian people, to proceed with the isolation of beneficial commensal strains such as Faecalibacterium prausnitzii, Akkermansia muciniphila and Oscillospiraceae, in a non-limitative way. Elderly and centenarian people will be recruited in nursing home among the Gerontopole of \"Ile de France\" network. Blood (serum + TruCulture tubes) and stools will be collected from each subject.","overall_status":"Terminated","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Bioaster","enrollment":20,"countries":["France"],"start_date":"2023-06-06","completion_date":"2023-10-18","last_update_date":"2024-03-19","source_url":"https://clinicaltrials.gov/study/NCT05701371","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Terminated. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T23:18:16.628904+00:00","last_seen_at":"2026-09-25T06:15:12.989+00:00","metadata":{"sex":"FEMALE","acronym":"BISCOTE","age_range":"95 Years","comparator":null,"organization":"Bioaster","interventions":["Biological samples collection"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Establishment of a bank of blood and faeces biological samples from centenarians people for research purposes — One day","Bacteria collection — One day","Fecal microbiota composition — One day","Immuno-modulatory properties of isolated strains — One day"],"design_description":null,"source_has_results":false},"controlled_terms":["Healthy Aging","Biological samples collection"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: centenarian.","quality_checked_at":"2026-09-25T06:15:13.224785+00:00","duplicate_cluster_key":"id:nct05701371","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2023-06-06 to 2023-10-18","comparator":null,"confidence":"structured-source","population":"FEMALE · 95 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:12.992Z","intervention":["Biological samples collection"],"participants":20,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Establishment of a bank of blood and faeces biological samples from centenarians people for research purposes — One day","Bacteria collection — One day","Fecal microbiota composition — One day","Immuno-modulatory properties of isolated strains — One day"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"centenarian-biology","is_published":true,"match_reasons":["Title contains controlled term: centenarian.","Abstract contains controlled term: centenarian.","Title supplies longevity context: centenarian.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Centenarian biology","slug":"centenarian-biology"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/27699","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}