{"type":"trials","record":{"id":27753,"source_id":"clinicaltrials-gov","external_id":"NCT05156918","title":"The Effects of High-Intensity Exercise on Biological Age","brief_summary":"The purpose of this graduate student research study is to determine if a high-intensity exercise program can slow or reverse biological (transcriptomic) aging and shed light on the underlying transcriptomic pathways involved.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Loma Linda University","enrollment":35,"countries":["United States"],"start_date":"2021-11-29","completion_date":"2022-06-28","last_update_date":"2022-06-30","source_url":"https://clinicaltrials.gov/study/NCT05156918","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T00:17:04.874284+00:00","last_seen_at":"2026-09-25T06:15:16.655+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"40 Years to 65 Years","comparator":"Control Group","organization":"Loma Linda University","interventions":["Exercise","Non Exercise"],"registry_source":"ClinicalTrials.gov","outcome_measures":["venipuncture procedure — Change between baseline and 30 days","Perceived stress scale survey — Change between baseline and 30 days","Pittsburgh Sleep Quality Index — Change between baseline and 30 days"],"design_description":"RANDOMIZED · PARALLEL · OTHER · NONE","source_has_results":false},"controlled_terms":["Exercise","Non Exercise"],"relevance_confidence":80,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: biological age.","quality_checked_at":"2026-09-25T06:15:16.736472+00:00","duplicate_cluster_key":"id:nct05156918","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2021-11-29 to 2022-06-28","comparator":"Control Group","confidence":"structured-source","population":"ALL · 40 Years to 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:16.655Z","intervention":["Exercise","Non Exercise"],"participants":35,"study_design":"RANDOMIZED · PARALLEL · OTHER · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["venipuncture procedure — Change between baseline and 30 days","Perceived stress scale survey — Change between baseline and 30 days","Pittsburgh Sleep Quality Index — Change between baseline and 30 days"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"biological-age-biomarkers","is_published":true,"match_reasons":["Title contains controlled term: biological age.","Title supplies longevity context: biological age.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Biological age biomarkers","slug":"biological-age-biomarkers"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/27753","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}