{"type":"trials","record":{"id":278,"source_id":"clinicaltrials-gov","external_id":"NCT05083546","title":"Methylglyoxal (MGO) Lowering Cocktail to Reduce Appetite in Obese Individuals","brief_summary":"Mechanisms that drive addiction to sugar rich foods are a major driving factor in the pathogenesis of obesity, which has become one of the most significant health care burdens. The molecular underpinnings of these hedonic mechanisms that drive addiction to sugar are poorly understood. The investigators demonstrated that methylglyoxal (MGO) derived Advanced Glycation Endproducts (AGEs) enhance food intake especially under a high sugar diet. The investigators identified a methylglyoxal (MGO) lowering cocktail, Gly-low, a combination of alpha-lipoic acid, nicotinamide, thiamine, pyridoxamine, and piperine that demonstrates a multimodal effect influencing many pathways related to aging including calorie restriction. Glycation lowering (Gly-low) treatment significantly reduces food intake and weight gain in the db/db mice that lack the leptin receptor. The investigators also extended the lif…","overall_status":"Withdrawn","phases":["PHASE1","PHASE2"],"study_type":"INTERVENTIONAL","sponsor":"University of California, San Francisco","enrollment":0,"countries":["United States"],"start_date":"2024-12-01","completion_date":"2026-12-01","last_update_date":"2025-08-29","source_url":"https://clinicaltrials.gov/study/NCT05083546","editorial_summary":"A registered PHASE1, PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Withdrawn. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-14T02:45:01.944738+00:00","last_seen_at":"2026-09-15T00:18:34.37+00:00","metadata":{"acronym":null,"organization":"University of California, San Francisco","source_has_results":false},"controlled_terms":[],"relevance_confidence":68,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Published automatically with 68% topic confidence after controlled-term evaluation.","quality_checked_at":"2026-09-15T02:15:56.576005+00:00","duplicate_cluster_key":"registry:nct05083546","duplicate_of_id":null,"clinical_trial_topics":[{"topic_slug":"caloric-restriction","is_published":true,"match_reasons":["Legacy trial evaluated automatically against controlled title, summary, and longevity-context rules."],"matched_fields":["abstract"],"relevance_score":68,"intelligence_topics":{"name":"Caloric restriction","slug":"caloric-restriction"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/278","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}