{"type":"trials","record":{"id":27846,"source_id":"clinicaltrials-gov","external_id":"NCT06210555","title":"Multiparametric MRI in a Prospective Cohort of Living Kidney Donors, Recipients, and Healthy Controls: Correlations With Markers of Renal Function, Fibrosis and Ageing","brief_summary":"Development of renal fibrosis is the irreversible culmination of various renal diseases and independently predicts adverse outcomes. Currently renal fibrosis can only be diagnosed by performing a renal biopsy. The procedure is invasive and is limited by sampling bias. In recent years there has been a significant development in magnetic resonance imaging (MRI) based techniques. MRI can provide highly detailed anatomical images. Other MRI measures allow quantitative measurements of perfusion, oxygenation, tissue stiffness and diffusion of water molecules within tissue. The combination of several MRI techniques sensitive to different biophysical tissue properties in a single scan session is referred to as multiparametric MRI (mpMRI). Emerging evidence suggests that mpMRI could represent a method for indirect characterization of renal microstructure and extent of fibrosis. So far, studies performed in living kidney donors and recipients have been mostly cross-sectional. For mpMRI to transition to the clinical setting there is a need for validation of MRI-based measures with currently used reference methods for quantifying renal function and fibrosis. The aim of this longitudinal observational study in a cohort of living kidney donors, recipients and healthy controls is to investigate the utility of repeated mpMRI over a period of 2 years. MRI-based measures will be compared to current reference methods for quantifying renal function and fibrosis. The investigators hypothesize that there will be significant correlations between MRI-based measures, renal function determined by precise measurement of glomerular filtration rate and extent of fibrosis determined by renal biopsy. MRI-based measures are expected to be predictive of renal function decline and development of renal fibrosis. This study could provide valuable data that will be helpful in moving the field of renal mpMRI forward, with the goal of providing a novel and non-invasive method for the diagnosis of renal pathology.","overall_status":"Recruiting","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Patrick Schjelderup","enrollment":96,"countries":["Denmark"],"start_date":"2024-10-29","completion_date":"2029-12-31","last_update_date":"2026-08-27","source_url":"https://clinicaltrials.gov/study/NCT06210555","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T00:17:06.581709+00:00","last_seen_at":"2026-09-25T06:20:12.788+00:00","metadata":{"sex":"ALL","acronym":"MpRenal","age_range":"18 Years to 80 Years","comparator":null,"organization":"Aalborg University Hospital","interventions":["Renal transplantation","Living kidney donation"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Correlation between MRI-based measures (T1/T2-mapping, ADC, ASL) and fibrosis quantified by morphometric evaluation ren…","Correlation between MRI-based measures (T1/T2-mapping, ADC, ASL) and measured GFR. — Multiparametric MRI and DTPA clear…","Diagnostic performance of MRI-based measures and biomarkers as regards to allograft fibrosis. — Multiparametric MRI and…","Predictive value of MRI-based measures and biomarkers of renal ageing and fibrosis as regards to development of allogra…"],"design_description":null,"source_has_results":false},"controlled_terms":["Kidney Transplantation","Multiparametric Magnetic Resonance Imaging","Living Donors","Renal Fibrosis","Senescence","Renal transplantation","Living kidney donation"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: fibrosis.","quality_checked_at":"2026-09-25T06:20:12.930719+00:00","duplicate_cluster_key":"id:nct06210555","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2024-10-29 to 2029-12-31","comparator":null,"confidence":"structured-source","population":"ALL · 18 Years to 80 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:12.788Z","intervention":["Renal transplantation","Living kidney donation"],"participants":96,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Correlation between MRI-based measures (T1/T2-mapping, ADC, ASL) and fibrosis quantified by morphometric evaluation ren…","Correlation between MRI-based measures (T1/T2-mapping, ADC, ASL) and measured GFR. — Multiparametric MRI and DTPA clear…","Diagnostic performance of MRI-based measures and biomarkers as regards to allograft fibrosis. — Multiparametric MRI and…","Predictive value of MRI-based measures and biomarkers of renal ageing and fibrosis as regards to development of allogra…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"extracellular-matrix-aging","is_published":true,"match_reasons":["Title contains controlled term: fibrosis.","Abstract contains controlled term: tissue stiffness, fibrosis.","Source terminology contains: fibrosis.","Title supplies longevity context: ageing.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Extracellular matrix ageing","slug":"extracellular-matrix-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/27846","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}